PET Visualized Stimulation of the Vestibular Organ in Menière's Disease

Louise Devantier; Allan K Hansen; Jens-Jacob Mølby-Henriksen; Christian Bech Christensen; Tina Lildal; Michael Pedersen; Måns Magnusson; Per Borghammer; Therese Ovesen

doi:10.3389/fneur.2020.00011

PET Visualized Stimulation of the Vestibular Organ in Menière's Disease

Louise Devantier, Allan K Hansen, Jens-Jacob Mølby-Henriksen, Christian Bech Christensen, Tina Lildal, Michael Pedersen, Måns Magnusson, Per Borghammer, Therese Ovesen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

Introduction: The cortical metabolic activity in patients with Menière's disease has not been investigated. The aim of this study was to investigate the 18F-FDG cerebral uptake in Menière's patients compared to healthy controls. Method: Eight patients with right-sided Menière's disease and fourteen healthy controls underwent a video head impulse test (vHIT), test of utricular function with ocular vestibular evoked myogenic potentials (oVEMP) and three 18F-FDG-based PET examinations of the brain. Participants were seated in a self-propelled chair, injected with 18F-FDG and then exposed to 35 min of chair motion stimulation, followed by a PET scan. Two types of natural vestibular stimuli were applied, predominantly toward the right horizontal semicircular canal (angular acceleration) and right utriculus (linear acceleration). For baseline scans, participants were injected with 18F-FDG while seated without movement. Results: Analyses of baseline scans revealed decreased 18F-FDG-uptake in the medial part of Heschl's gyrus in the left hemisphere in patients with Menière's disease compared to healthy controls. During angular vestibular stimulation there was also a significantly decreased 18F-FDG uptake in the intersection between the medial part of Heschl's gyrus and the parietal operculum in the left hemisphere and bilaterally in the posterior part of insula. During linear stimulation, Menière's patients showed decreased 18F-FDG uptake in the medial part of Heschl's gyrus in the right hemisphere and also bilaterally in the posterior insula. In addition, decreased 18F-FDG uptake was seen in the thalamus during vestibular stimulation. Conclusion: Heschl's gyrus, the posterior part of insula, and thalamus have previously been shown to be core areas for processing vestibular inputs. Patients with Menière's disease solely differed from the healthy controls with lower cortical activity in these areas at baseline and during natural vestibular stimulation.

Original language	English
Article number	11
Journal	Frontiers in Neurology
Volume	11
Number of pages	7
ISSN	1664-2295
DOIs	https://doi.org/10.3389/fneur.2020.00011
Publication status	Published - 2020

Keywords

Menière's disease
central vestibular system
neuroimaging
positron emission tomography
vestibular cortex

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10.3389/fneur.2020.00011

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@article{163fbffc1444487ebffd672591df5555,

title = "PET Visualized Stimulation of the Vestibular Organ in Meni{\`e}re's Disease",

abstract = "Introduction: The cortical metabolic activity in patients with Meni{\`e}re's disease has not been investigated. The aim of this study was to investigate the 18F-FDG cerebral uptake in Meni{\`e}re's patients compared to healthy controls. Method: Eight patients with right-sided Meni{\`e}re's disease and fourteen healthy controls underwent a video head impulse test (vHIT), test of utricular function with ocular vestibular evoked myogenic potentials (oVEMP) and three 18F-FDG-based PET examinations of the brain. Participants were seated in a self-propelled chair, injected with 18F-FDG and then exposed to 35 min of chair motion stimulation, followed by a PET scan. Two types of natural vestibular stimuli were applied, predominantly toward the right horizontal semicircular canal (angular acceleration) and right utriculus (linear acceleration). For baseline scans, participants were injected with 18F-FDG while seated without movement. Results: Analyses of baseline scans revealed decreased 18F-FDG-uptake in the medial part of Heschl's gyrus in the left hemisphere in patients with Meni{\`e}re's disease compared to healthy controls. During angular vestibular stimulation there was also a significantly decreased 18F-FDG uptake in the intersection between the medial part of Heschl's gyrus and the parietal operculum in the left hemisphere and bilaterally in the posterior part of insula. During linear stimulation, Meni{\`e}re's patients showed decreased 18F-FDG uptake in the medial part of Heschl's gyrus in the right hemisphere and also bilaterally in the posterior insula. In addition, decreased 18F-FDG uptake was seen in the thalamus during vestibular stimulation. Conclusion: Heschl's gyrus, the posterior part of insula, and thalamus have previously been shown to be core areas for processing vestibular inputs. Patients with Meni{\`e}re's disease solely differed from the healthy controls with lower cortical activity in these areas at baseline and during natural vestibular stimulation.",

keywords = "Meni{\`e}re's disease, central vestibular system, neuroimaging, positron emission tomography, vestibular cortex",

author = "Louise Devantier and Hansen, {Allan K} and Jens-Jacob M{\o}lby-Henriksen and Christensen, {Christian Bech} and Tina Lildal and Michael Pedersen and M{\aa}ns Magnusson and Per Borghammer and Therese Ovesen",

note = "Copyright {\textcopyright} 2020 Devantier, Hansen, M{\o}lby-Henriksen, Christensen, Lildal, Pedersen, Magnusson, Borghammer and Ovesen.",

year = "2020",

doi = "10.3389/fneur.2020.00011",

language = "English",

volume = "11",

journal = "Frontiers in Neurology",

issn = "1664-2295",

publisher = "Frontiers Research Foundation",

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TY - JOUR

T1 - PET Visualized Stimulation of the Vestibular Organ in Menière's Disease

AU - Devantier, Louise

AU - Hansen, Allan K

AU - Mølby-Henriksen, Jens-Jacob

AU - Christensen, Christian Bech

AU - Lildal, Tina

AU - Pedersen, Michael

AU - Magnusson, Måns

AU - Borghammer, Per

AU - Ovesen, Therese

PY - 2020

Y1 - 2020

N2 - Introduction: The cortical metabolic activity in patients with Menière's disease has not been investigated. The aim of this study was to investigate the 18F-FDG cerebral uptake in Menière's patients compared to healthy controls. Method: Eight patients with right-sided Menière's disease and fourteen healthy controls underwent a video head impulse test (vHIT), test of utricular function with ocular vestibular evoked myogenic potentials (oVEMP) and three 18F-FDG-based PET examinations of the brain. Participants were seated in a self-propelled chair, injected with 18F-FDG and then exposed to 35 min of chair motion stimulation, followed by a PET scan. Two types of natural vestibular stimuli were applied, predominantly toward the right horizontal semicircular canal (angular acceleration) and right utriculus (linear acceleration). For baseline scans, participants were injected with 18F-FDG while seated without movement. Results: Analyses of baseline scans revealed decreased 18F-FDG-uptake in the medial part of Heschl's gyrus in the left hemisphere in patients with Menière's disease compared to healthy controls. During angular vestibular stimulation there was also a significantly decreased 18F-FDG uptake in the intersection between the medial part of Heschl's gyrus and the parietal operculum in the left hemisphere and bilaterally in the posterior part of insula. During linear stimulation, Menière's patients showed decreased 18F-FDG uptake in the medial part of Heschl's gyrus in the right hemisphere and also bilaterally in the posterior insula. In addition, decreased 18F-FDG uptake was seen in the thalamus during vestibular stimulation. Conclusion: Heschl's gyrus, the posterior part of insula, and thalamus have previously been shown to be core areas for processing vestibular inputs. Patients with Menière's disease solely differed from the healthy controls with lower cortical activity in these areas at baseline and during natural vestibular stimulation.

AB - Introduction: The cortical metabolic activity in patients with Menière's disease has not been investigated. The aim of this study was to investigate the 18F-FDG cerebral uptake in Menière's patients compared to healthy controls. Method: Eight patients with right-sided Menière's disease and fourteen healthy controls underwent a video head impulse test (vHIT), test of utricular function with ocular vestibular evoked myogenic potentials (oVEMP) and three 18F-FDG-based PET examinations of the brain. Participants were seated in a self-propelled chair, injected with 18F-FDG and then exposed to 35 min of chair motion stimulation, followed by a PET scan. Two types of natural vestibular stimuli were applied, predominantly toward the right horizontal semicircular canal (angular acceleration) and right utriculus (linear acceleration). For baseline scans, participants were injected with 18F-FDG while seated without movement. Results: Analyses of baseline scans revealed decreased 18F-FDG-uptake in the medial part of Heschl's gyrus in the left hemisphere in patients with Menière's disease compared to healthy controls. During angular vestibular stimulation there was also a significantly decreased 18F-FDG uptake in the intersection between the medial part of Heschl's gyrus and the parietal operculum in the left hemisphere and bilaterally in the posterior part of insula. During linear stimulation, Menière's patients showed decreased 18F-FDG uptake in the medial part of Heschl's gyrus in the right hemisphere and also bilaterally in the posterior insula. In addition, decreased 18F-FDG uptake was seen in the thalamus during vestibular stimulation. Conclusion: Heschl's gyrus, the posterior part of insula, and thalamus have previously been shown to be core areas for processing vestibular inputs. Patients with Menière's disease solely differed from the healthy controls with lower cortical activity in these areas at baseline and during natural vestibular stimulation.

KW - Menière's disease

KW - central vestibular system

KW - neuroimaging

KW - positron emission tomography

KW - vestibular cortex

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U2 - 10.3389/fneur.2020.00011

DO - 10.3389/fneur.2020.00011

M3 - Journal article

C2 - 32047473

SN - 1664-2295

VL - 11

JO - Frontiers in Neurology

JF - Frontiers in Neurology

M1 - 11

ER -

PET Visualized Stimulation of the Vestibular Organ in Menière's Disease

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Keywords

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