You are here:
» Persistent Symptoms and Sequelae After Severe Acute Respi...
About Aarhus University
Persistent Symptoms and Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection Not Requiring Hospitalization: Results From Testing Denmark, a Danish Cross-sectional Survey
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1093/ofid/ofac679
Final published version
- Maarten van Wijhe, Roskilde University ,
- Kamille Fogh, University of Copenhagen ,
- Steen Ethelberg, Statens Serum Institut, University of Copenhagen, Denmark
- Kasper Karmark Iversen, University of Copenhagen ,
- Henrik Nielsen, Aalborg University ,
- Lars Jørgen Østergaard
- Berit Andersen
- Henning Bundgaard, University of Copenhagen ,
- Charlotte S. Jørgensen, Statens Serum Institut ,
- Bibi F S S Scharff, University of Copenhagen ,
- Svend Ellermann-Eriksen
- Isik S Johansen, University of Southern Denmark, Denmark
- Anders Fomsgaard, Statens Serum Institut ,
- Tyra Grove Krause, Statens Serum Institut, Denmark
- Lothar Wiese, Sjællands Universitetshospital, Denmark
- Thea K.Fischer, University of Copenhagen ,
- Kåre Mølbak, Statens Serumsinstitut, University of Copenhagen ,
- Thomas Benfield, University of Copenhagen ,
- Fredrik Folke, University of Copenhagen, Emergency Medical Services, Denmark
- Freddy Lippert, University of Copenhagen, Emergency Medical Services, Denmark
- Sisse Rye Ostrowski, University of Copenhagen, Denmark
- Anders Koch, University of Copenhagen ,
- Christian Erikstrup
- Anne-Marie Vangsted, Statens Serum Institut ,
- Anna Irene Vedel Sørensen , Statens Serum Institut ,
- Henrik Ullum, Statens Serum Institut, Denmark
- Robert Leo Skov, Statens Serum Institut, Denmark
- Lone Simonsen, Roskilde University ,
- Susanne Dam Nielsen, University of Copenhagen
- Department of Clinical Medicine - Department of Infectious Diseases
- Department of Clinical Medicine - The Department of Public Health Programs, Randers
- Department of Clinical Medicine - Tilknyttede Klinisk Medicin
- Department of Clinical Medicine
- Department of Clinical Medicine - Department of Clinical Microbiology
- Department of Clinical Medicine - Department of Clinical Immunology
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with persistent symptoms ("long COVID"). We assessed the burden of long COVID among nonhospitalized adults with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection.
Methods: In the fall of 2020, a cross-sectional survey was performed in the adult Danish general population. This included a self-administered point-of-care test for SARS-CoV-2 antibodies, the Short Form Health Survey (SF-12), and coronavirus disease 2019 (COVID-19)-associated symptom questions. Nonhospitalized respondents with a positive SARS-CoV-2 PCR test ≥12 weeks before the survey (cases) were matched (1:10) to seronegative controls on age, sex, and body mass index. Propensity score-weighted odds ratios (ORs) and ORs for risk factors were estimated for each health outcome.
Results: In total, 742 cases and 7420 controls were included. The attributable risk of at least 1 long-COVID symptom was 25.0 per 100 cases (95% confidence interval [CI], 22.2-27.4). Compared to controls, cases reported worse general health (OR, 5.9 [95% CI, 5.0-7.0]) and had higher odds for a broad range of symptoms, particularly loss of taste (OR, 11.8 [95% CI, 9.5-14.6]) and smell (OR, 11.2 [95% CI, 9.1-13.9]). Physical and Mental Component Summary scores were also significantly reduced with differences of -2.5 (95% CI, -3.1 to -1.8) and -2.0 (95% CI, -2.7 to -1.2), respectively. Female sex and severity of initial infection were major risk factors for long COVID.
Conclusions: Nonhospitalized SARS-CoV-2 PCR-positive individuals had significantly reduced physical and mental health, and 1 in 4 reported persistence of at least 1 long-COVID symptom.
Methods: In the fall of 2020, a cross-sectional survey was performed in the adult Danish general population. This included a self-administered point-of-care test for SARS-CoV-2 antibodies, the Short Form Health Survey (SF-12), and coronavirus disease 2019 (COVID-19)-associated symptom questions. Nonhospitalized respondents with a positive SARS-CoV-2 PCR test ≥12 weeks before the survey (cases) were matched (1:10) to seronegative controls on age, sex, and body mass index. Propensity score-weighted odds ratios (ORs) and ORs for risk factors were estimated for each health outcome.
Results: In total, 742 cases and 7420 controls were included. The attributable risk of at least 1 long-COVID symptom was 25.0 per 100 cases (95% confidence interval [CI], 22.2-27.4). Compared to controls, cases reported worse general health (OR, 5.9 [95% CI, 5.0-7.0]) and had higher odds for a broad range of symptoms, particularly loss of taste (OR, 11.8 [95% CI, 9.5-14.6]) and smell (OR, 11.2 [95% CI, 9.1-13.9]). Physical and Mental Component Summary scores were also significantly reduced with differences of -2.5 (95% CI, -3.1 to -1.8) and -2.0 (95% CI, -2.7 to -1.2), respectively. Female sex and severity of initial infection were major risk factors for long COVID.
Conclusions: Nonhospitalized SARS-CoV-2 PCR-positive individuals had significantly reduced physical and mental health, and 1 in 4 reported persistence of at least 1 long-COVID symptom.
| Original language | English |
|---|---|
| Article number | ofac679 |
| Journal | Open Forum Infectious Diseases |
| Volume | 10 |
| Issue | 1 |
| ISSN | 2328-8957 |
| DOIs | |
| Publication status | Published - Jan 2023 |
Bibliographical note
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
See relations at Aarhus University Citationformats
ID: 306193310