Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

Ida Monrad*, Signe Risgaard Sahlertz, Stine Sofie Frank Nielsen, Louise Ørnskov Pedersen, Mikkel Steen Petersen, Carl Mathias Kobel, Irene Harder Tarpgaard, Merete Storgaard, Klaus Leth Mortensen, Mariane H. Schleimann, Martin Tolstrup, Line K. Vibholm

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

Original languageEnglish
Article numberofab295
JournalOpen Forum Infectious Diseases
Volume8
Issue7
Number of pages5
ISSN2328-8957
DOIs
Publication statusPublished - Jul 2021

Keywords

  • CLL
  • persistent infection
  • SARS-CoV-2
  • viral evolution

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