Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Nicola Pavese
  • Gino Giannaccini, University of Pisa
  • ,
  • Laura Betti, University of Pisa
  • ,
  • Stefano Ferrari, University of Pisa
  • ,
  • Enrica Bonanni, University of Pisa
  • ,
  • Ubaldo Bonuccelli, University of Pisa
  • ,
  • Luigi Murri, University of Pisa
  • ,
  • Antonio Lucacchini, University of Pisa

The kinetic parameters at equilibrium of peripheral benzodiazepine receptors in platelets, lymphocytes and granulocytes of 15 patients affected by migraine without aura were tested using [3H]PK 11195, a specific radioligand for this receptor and compared with the same number of healthy controls: a statistically significant increase (platelets 212%, lymphocytes 203%, granulocites 171%, as absolute percentage) in the maximal number of binding sites (B(max)) in all three patient samples, compared with healthy controls was detected; on the contrary, the values of the dissociation constant (K(d)) at equilibrium do not show any statistically significant variations between the two groups. These data further confirm the presence of peripheral biochemical alterations in migraine without aura. As peripheral benzodiazepine receptors appear to be involved in the regulation of the mitochondrial respiratory chain, the observed increase in B(max) might be related to the mitochondrial anomalies found in migraine disorders. Copyright (C) 2000.

Original languageEnglish
JournalNeurochemistry International
Volume37
Issue4
Pages (from-to)363-368
Number of pages6
ISSN0197-0186
DOIs
Publication statusPublished - 1 Oct 2000
Externally publishedYes

    Research areas

  • A carboxamide, Peripheral benzodiazepine receptors, PK 11195, Role in the migraine without aura

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