Perioperative anaesthesia by local infiltration following median sternotomy - a study protocol

TY - JOUR

T1 - Perioperative anaesthesia by local infiltration following median sternotomy - a study protocol

AU - Rasmussen, Jonas Juel

AU - Bisgaard, Jannie

AU - Juhl-Olsen, Peter

AU - Hønge, Jesper Langhoff

AU - Modrau, Ivy Susanne

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2023/8

Y1 - 2023/8

N2 - INTRODUCTION. Post-operative pain following open heart surgery is a clinical challenge usually requiring significant amounts of opioids. Long-acting local infiltration anaesthesia may effectively reduce post-operative opioid consumption and improve recovery. The trial is a publicly funded, double-blinded, randomised, placebo-controlled trial evaluating the effect of long-acting local infiltration anaesthesia in open heart surgery. METHODS. Two Danish centres are planning to randomise 100 patients undergoing coronary artery bypass grafting to treatment with long-acting infiltration anaesthesia or placebo. We compare an active solution of bupivacaine, adrenaline, clonidine and dexamethasone with saline placebo. The primary outcome measure is the accumulated opioid use within the first 24 post-operative hours. Secondary outcome measures include evaluation of respiratory function, patient-reported pain scores, mobilisation, opioid-associated side effects and long-term opioid consumption. CONCLUSION. This trial will define whether the use of long-acting infiltration anaesthesia during heart surgery may reduce acute and prolonged post-operative opioid consumption. Reduction of opioid-related adverse effects may improve recovery.

AB - INTRODUCTION. Post-operative pain following open heart surgery is a clinical challenge usually requiring significant amounts of opioids. Long-acting local infiltration anaesthesia may effectively reduce post-operative opioid consumption and improve recovery. The trial is a publicly funded, double-blinded, randomised, placebo-controlled trial evaluating the effect of long-acting local infiltration anaesthesia in open heart surgery. METHODS. Two Danish centres are planning to randomise 100 patients undergoing coronary artery bypass grafting to treatment with long-acting infiltration anaesthesia or placebo. We compare an active solution of bupivacaine, adrenaline, clonidine and dexamethasone with saline placebo. The primary outcome measure is the accumulated opioid use within the first 24 post-operative hours. Secondary outcome measures include evaluation of respiratory function, patient-reported pain scores, mobilisation, opioid-associated side effects and long-term opioid consumption. CONCLUSION. This trial will define whether the use of long-acting infiltration anaesthesia during heart surgery may reduce acute and prolonged post-operative opioid consumption. Reduction of opioid-related adverse effects may improve recovery.

KW - Humans

KW - Sternotomy/adverse effects

KW - Analgesics, Opioid/therapeutic use

KW - Anesthesia

KW - Anesthesiology

KW - Plastic Surgery Procedures

KW - Drug-Related Side Effects and Adverse Reactions

KW - Randomized Controlled Trials as Topic

UR - http://www.scopus.com/inward/record.url?scp=85168748612&partnerID=8YFLogxK

M3 - Journal article

C2 - 37622639

SN - 2245-1919

VL - 70

JO - Danish Medical Journal

JF - Danish Medical Journal

IS - 9

M1 - A02230072

ER -