Pd-catalyzed thiocarbonylation with stoichiometric carbon monoxide: scope and applications

TY - JOUR

T1 - Pd-catalyzed thiocarbonylation with stoichiometric carbon monoxide

T2 - scope and applications

AU - Burhardt, Mia

AU - Taaning, Rolf H

AU - Skrydstrup, Troels

PY - 2013

Y1 - 2013

N2 - A general protocol for the Pd-catalyzed thiocarbonylation of aryl iodides with stoichiometric carbon monoxide has been established employing a catalytic system composed of Pd(OAc)(2) and DPEphos with low catalyst loading (1 mol %). Both electron-rich and -deficient aryl iodides proved effective for these couplings with aryl and alkyl thiols. The choice of the metal ligands and the solvent system was crucial for the efficiency and chemoselectivity of these transformations.

AB - A general protocol for the Pd-catalyzed thiocarbonylation of aryl iodides with stoichiometric carbon monoxide has been established employing a catalytic system composed of Pd(OAc)(2) and DPEphos with low catalyst loading (1 mol %). Both electron-rich and -deficient aryl iodides proved effective for these couplings with aryl and alkyl thiols. The choice of the metal ligands and the solvent system was crucial for the efficiency and chemoselectivity of these transformations.

U2 - 10.1021/ol400138m

DO - 10.1021/ol400138m

M3 - Journal article

C2 - 23383647

SN - 1523-7060

VL - 15

SP - 948

EP - 951

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -