Patterns of Palliative Chemotherapy and Survival in Patients with Pancreatic Cancer Focusing on Age: A Nationwide Real-World Danish Registry Study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Louise S. Rasmussen, Aalborg University, Aalborg Universitetshospital
  • ,
  • Claus W. Fristrup, University of Southern Denmark
  • ,
  • Benny V. Jensen, Herlev Hospital
  • ,
  • Per Pfeiffer, University of Southern Denmark
  • ,
  • Britta Weber
  • ,
  • Mette K. Yilmaz, Aalborg Universitetshospital
  • ,
  • Laurids Poulsen, Aalborg University, Aalborg Universitetshospital
  • ,
  • Morten Ladekarl
  • Kell Østerlind, Nordsjællands Hospital - Hillerød
  • ,
  • Jim S. Larsen, Sjællands Universitetshospital
  • ,
  • Halla Skuladottir
  • Martin Bøgsted
  • Ursula G. Falkmer, Aalborg University

Objectives The aim of this study was to identify patterns of palliative chemotherapy (CTh) and the associated overall survival (OS) in patients with pancreatic cancer, with specific focus on age. Methods Between May 1, 2011, and April 30, 2016, 4260 patients were registered in the Danish Pancreatic Cancer Database. The 1715 patients receiving palliative CTh were retrieved. Age was grouped into less than 70, 70 to less than 75, and 75 years or more. Results Of the 1715 patients receiving first-line CTh, 586 (34%) underwent second-line CTh and 151 (9%) third-line CTh. First-line gemcitabine resulted in a significant worse survival compared with combination CTh, hazard ratio 1.51. For combination CTh, OS differed between the age groups, P < 0.01. The median OS in the less than 70 years (n = 547), 70 to less than 75 years (n = 163), and 75 years or more (n = 67) groups were 9.3, 9.6, and 7.2 months, respectively. No differences in survival were observed among patients receiving first-line gemcitabine (P = 0.35). Conclusions Our findings are useful in treatment-related decision making in patients with pancreatic cancer. A significant survival benefit was observed for all patients after first-line combination CTh. The effect of combination CTh was most prominent among patients aged less than 75 years. By age, no differences in survival were observed in those receiving gemcitabine.

Original languageEnglish
JournalPancreas
Volume50
Issue5
Pages (from-to)685-695
Number of pages11
ISSN0885-3177
DOIs
Publication statusPublished - May 2021

Bibliographical note

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

    Research areas

  • age, palliative chemotherapy pattern, pancreatic cancer, registry study, second-line treatment, survival

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