Patient-centred outcome following endoscopic management of benign central airway obstruction

Mads Bøgh; Dalia Gustaityté Larsen; Matilde Lonka; Sten Schytte; Ulrik Pedersen; Søren Gade; Padraig O'Leary; Thomas Kjaergaard

doi:10.1007/s00405-025-09230-1

Patient-centred outcome following endoscopic management of benign central airway obstruction

Mads Bøgh, Dalia Gustaityté Larsen, Matilde Lonka, Sten Schytte, Ulrik Pedersen, Søren Gade, Padraig O'Leary, Thomas Kjaergaard

Department of Clinical Medicine - The Department of Oto-Rhino-Laryngology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

PURPOSE: To examine patient-centred outcome following endoscopic treatment of central airway stenosis in terms of days alive and out of hospital (DAOH), need for re-intervention, and complications, with reference to aetiology of disease and applied treatment methodology.

METHODS: Analyses were based on data from consecutive adult patients treated endoscopically for benign central airway obstruction at Aarhus University Hospital from 2012 to 2022, with a minimum follow-up of one year. DAOH was calculated for 30 and 365 days. Complications were graded based on the Clavien-Dindo classification. Univariate and multivariate analyses were performed to identify predictors for DAOH, re-intervention and complications.

RESULTS: 82 consecutive adult patients underwent endoscopic treatment during the period of inclusion, comprising a total of 175 dilatations, 42 benign tumour resections, and 67 stent insertions. Multiple interventions and short re-intervention intervals was more likely amongst patients reporting significant preoperative dyspnoea or requiring preoperative respiratory support, as well as patients treated with endoscopic insertion of silicone stents. The overall complication rate per procedure was 11.7%, and complications were more likely to occur in patients with high age, high BMI and comorbidity. Overall DAOH during the first year after intervention was 343 days, lowest amongst patients with tracheobronchomalacia or severe airway stenosis, and in those who underwent endoscopic stent insertion.

CONCLUSION: Endoscopic treatment is a safe and viable intervention in the management of benign central airway obstruction in adults with few complications and a high overall outcome.

Original language	English
Journal	European Archives of Oto-Rhino-Laryngology
Pages (from-to)	2001-2007
Number of pages	7
ISSN	0937-4477
DOIs	https://doi.org/10.1007/s00405-025-09230-1
Publication status	Published - Apr 2025

Keywords

Benign
Central airway obstruction
Patient-relevant outcome
Postoperative complications
Therapeutic bronchoscopy
Tracheobronchomalacia

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10.1007/s00405-025-09230-1

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title = "Patient-centred outcome following endoscopic management of benign central airway obstruction",

abstract = "PURPOSE: To examine patient-centred outcome following endoscopic treatment of central airway stenosis in terms of days alive and out of hospital (DAOH), need for re-intervention, and complications, with reference to aetiology of disease and applied treatment methodology.METHODS: Analyses were based on data from consecutive adult patients treated endoscopically for benign central airway obstruction at Aarhus University Hospital from 2012 to 2022, with a minimum follow-up of one year. DAOH was calculated for 30 and 365 days. Complications were graded based on the Clavien-Dindo classification. Univariate and multivariate analyses were performed to identify predictors for DAOH, re-intervention and complications.RESULTS: 82 consecutive adult patients underwent endoscopic treatment during the period of inclusion, comprising a total of 175 dilatations, 42 benign tumour resections, and 67 stent insertions. Multiple interventions and short re-intervention intervals was more likely amongst patients reporting significant preoperative dyspnoea or requiring preoperative respiratory support, as well as patients treated with endoscopic insertion of silicone stents. The overall complication rate per procedure was 11.7%, and complications were more likely to occur in patients with high age, high BMI and comorbidity. Overall DAOH during the first year after intervention was 343 days, lowest amongst patients with tracheobronchomalacia or severe airway stenosis, and in those who underwent endoscopic stent insertion.CONCLUSION: Endoscopic treatment is a safe and viable intervention in the management of benign central airway obstruction in adults with few complications and a high overall outcome.",

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author = "Mads B{\o}gh and Larsen, {Dalia Gustaityt{\'e}} and Matilde Lonka and Sten Schytte and Ulrik Pedersen and S{\o}ren Gade and Padraig O'Leary and Thomas Kjaergaard",

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doi = "10.1007/s00405-025-09230-1",

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Patient-centred outcome following endoscopic management of benign central airway obstruction. / Bøgh, Mads ; Larsen, Dalia Gustaityté; Lonka, Matilde et al.
In: European Archives of Oto-Rhino-Laryngology, 04.2025, p. 2001-2007.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Patient-centred outcome following endoscopic management of benign central airway obstruction

AU - Bøgh, Mads

AU - Larsen, Dalia Gustaityté

AU - Lonka, Matilde

AU - Schytte, Sten

AU - Pedersen, Ulrik

AU - Gade, Søren

AU - O'Leary, Padraig

AU - Kjaergaard, Thomas

PY - 2025/4

Y1 - 2025/4

N2 - PURPOSE: To examine patient-centred outcome following endoscopic treatment of central airway stenosis in terms of days alive and out of hospital (DAOH), need for re-intervention, and complications, with reference to aetiology of disease and applied treatment methodology.METHODS: Analyses were based on data from consecutive adult patients treated endoscopically for benign central airway obstruction at Aarhus University Hospital from 2012 to 2022, with a minimum follow-up of one year. DAOH was calculated for 30 and 365 days. Complications were graded based on the Clavien-Dindo classification. Univariate and multivariate analyses were performed to identify predictors for DAOH, re-intervention and complications.RESULTS: 82 consecutive adult patients underwent endoscopic treatment during the period of inclusion, comprising a total of 175 dilatations, 42 benign tumour resections, and 67 stent insertions. Multiple interventions and short re-intervention intervals was more likely amongst patients reporting significant preoperative dyspnoea or requiring preoperative respiratory support, as well as patients treated with endoscopic insertion of silicone stents. The overall complication rate per procedure was 11.7%, and complications were more likely to occur in patients with high age, high BMI and comorbidity. Overall DAOH during the first year after intervention was 343 days, lowest amongst patients with tracheobronchomalacia or severe airway stenosis, and in those who underwent endoscopic stent insertion.CONCLUSION: Endoscopic treatment is a safe and viable intervention in the management of benign central airway obstruction in adults with few complications and a high overall outcome.

AB - PURPOSE: To examine patient-centred outcome following endoscopic treatment of central airway stenosis in terms of days alive and out of hospital (DAOH), need for re-intervention, and complications, with reference to aetiology of disease and applied treatment methodology.METHODS: Analyses were based on data from consecutive adult patients treated endoscopically for benign central airway obstruction at Aarhus University Hospital from 2012 to 2022, with a minimum follow-up of one year. DAOH was calculated for 30 and 365 days. Complications were graded based on the Clavien-Dindo classification. Univariate and multivariate analyses were performed to identify predictors for DAOH, re-intervention and complications.RESULTS: 82 consecutive adult patients underwent endoscopic treatment during the period of inclusion, comprising a total of 175 dilatations, 42 benign tumour resections, and 67 stent insertions. Multiple interventions and short re-intervention intervals was more likely amongst patients reporting significant preoperative dyspnoea or requiring preoperative respiratory support, as well as patients treated with endoscopic insertion of silicone stents. The overall complication rate per procedure was 11.7%, and complications were more likely to occur in patients with high age, high BMI and comorbidity. Overall DAOH during the first year after intervention was 343 days, lowest amongst patients with tracheobronchomalacia or severe airway stenosis, and in those who underwent endoscopic stent insertion.CONCLUSION: Endoscopic treatment is a safe and viable intervention in the management of benign central airway obstruction in adults with few complications and a high overall outcome.

KW - Benign

KW - Central airway obstruction

KW - Patient-relevant outcome

KW - Postoperative complications

KW - Therapeutic bronchoscopy

KW - Tracheobronchomalacia

UR - http://www.scopus.com/inward/record.url?scp=85218674466&partnerID=8YFLogxK

U2 - 10.1007/s00405-025-09230-1

DO - 10.1007/s00405-025-09230-1

M3 - Journal article

C2 - 39979626

SN - 0937-4477

SP - 2001

EP - 2007

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

ER -

Patient-centred outcome following endoscopic management of benign central airway obstruction

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Keywords

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