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Pathological gambling: Relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  • Ericka Peterson, Denmark
  • Arne Møller
  • Doris Doudet, Denmark
  • Christopher Bailey
  • Kim Vang Hansen
  • ,
  • Anders Rodell, Denmark
  • Jakob Linnet, Denmark
  • Albert Gjedde, Denmark
  • Positron Emission Tomography Center
  • Center for Functionally Integrative Neuroscience
Absent Skin Conductance Response (SCR) in pathological gambling (PG) may relate to dopaminergic
mechanisms. We recruited equal numbers of PG subjects and healthy control (HC) subjects, and
then tested the claim that SCR is less conditioned by dopaminergic activity in PG subjects. During
active gambling, SCR differed in PG and HC subjects (Pb0.05), but positron emission tomography
revealed the same dopamine receptor availability. However, highly sensation-seeking (HS) PG
subjects had lower dopamine receptor availability (Pb0.0001) in the baseline, compared to normal
sensation-seeking (NS) PG subjects. We find that HS versus NS controls had the same observation of
significant increase of binding potential (BPND) in high compared to normal sensation seekers. In
both groups, PG and HC, highly sensation-seeking subjects had significant increase of receptor
availability in striatum, compared to normally sensation-seeking subjects, separately (Pb0.05 and
P=0.02, respectively) and together (Pb0.0005). We conclude that SCR is less conditioned by
dopaminergic activity in highly sensation-seeking subjects, regardless of PG status.
Original languageEnglish
JournalEuropean Neuropsychopharmacology
Volume20
Pages (from-to)766–775
Number of pages10
ISSN0924-977X
Publication statusPublished - 2010

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