Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids

Fatemeh Mirab; Mitra Pirhaghi; Daniel E Otzen; Ali Akbar Saboury

doi:10.1016/j.bbadis.2025.167862

Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids

Fatemeh Mirab, Mitra Pirhaghi, Daniel E Otzen, Ali Akbar Saboury

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the abnormal accumulation of alpha-synuclein (α-Syn). Recent research emphasizes the significant role of the gut microbiota, the diverse community of microbes living in the intestines, in modulating α-Syn pathology. This review explores the bi-directional communication along the microbiota-gut-brain axis, highlighting the paradoxical impact of two gut microbiota metabolites-functional bacterial amyloids (FuBA) and vitamins-on neurodegenerative diseases, particularly PD. FuBA contributes to PD pathogenesis by promoting α-Syn aggregation, while vitamins offer neuroprotection through their anti-amyloidogenic, antioxidant, and anti-inflammatory properties. Understanding these processes could lead to precision clinical approaches and novel strategies for managing and preventing PD.

Original language	English
Journal	B B A - Molecular Basis of Disease
Pages (from-to)	167862
ISSN	0925-4439
DOIs	https://doi.org/10.1016/j.bbadis.2025.167862
Publication status	E-pub / Early view - 18 Apr 2025

Access to Document

10.1016/j.bbadis.2025.167862

Cite this

@article{6bf174f66ada4152a7e15458240f7332,

title = "Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids",

abstract = "Parkinson's disease (PD) is a neurodegenerative disorder characterized by the abnormal accumulation of alpha-synuclein (α-Syn). Recent research emphasizes the significant role of the gut microbiota, the diverse community of microbes living in the intestines, in modulating α-Syn pathology. This review explores the bi-directional communication along the microbiota-gut-brain axis, highlighting the paradoxical impact of two gut microbiota metabolites-functional bacterial amyloids (FuBA) and vitamins-on neurodegenerative diseases, particularly PD. FuBA contributes to PD pathogenesis by promoting α-Syn aggregation, while vitamins offer neuroprotection through their anti-amyloidogenic, antioxidant, and anti-inflammatory properties. Understanding these processes could lead to precision clinical approaches and novel strategies for managing and preventing PD.",

author = "Fatemeh Mirab and Mitra Pirhaghi and Otzen, {Daniel E} and Saboury, {Ali Akbar}",

note = "Copyright {\textcopyright} 2025. Published by Elsevier B.V.",

year = "2025",

month = apr,

day = "18",

doi = "10.1016/j.bbadis.2025.167862",

language = "English",

pages = "167862",

journal = "B B A - Molecular Basis of Disease",

issn = "0925-4439",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Parkinson's disease and gut microbiota metabolites

T2 - The dual impact of vitamins and functional amyloids

AU - Mirab, Fatemeh

AU - Pirhaghi, Mitra

AU - Otzen, Daniel E

AU - Saboury, Ali Akbar

PY - 2025/4/18

Y1 - 2025/4/18

N2 - Parkinson's disease (PD) is a neurodegenerative disorder characterized by the abnormal accumulation of alpha-synuclein (α-Syn). Recent research emphasizes the significant role of the gut microbiota, the diverse community of microbes living in the intestines, in modulating α-Syn pathology. This review explores the bi-directional communication along the microbiota-gut-brain axis, highlighting the paradoxical impact of two gut microbiota metabolites-functional bacterial amyloids (FuBA) and vitamins-on neurodegenerative diseases, particularly PD. FuBA contributes to PD pathogenesis by promoting α-Syn aggregation, while vitamins offer neuroprotection through their anti-amyloidogenic, antioxidant, and anti-inflammatory properties. Understanding these processes could lead to precision clinical approaches and novel strategies for managing and preventing PD.

AB - Parkinson's disease (PD) is a neurodegenerative disorder characterized by the abnormal accumulation of alpha-synuclein (α-Syn). Recent research emphasizes the significant role of the gut microbiota, the diverse community of microbes living in the intestines, in modulating α-Syn pathology. This review explores the bi-directional communication along the microbiota-gut-brain axis, highlighting the paradoxical impact of two gut microbiota metabolites-functional bacterial amyloids (FuBA) and vitamins-on neurodegenerative diseases, particularly PD. FuBA contributes to PD pathogenesis by promoting α-Syn aggregation, while vitamins offer neuroprotection through their anti-amyloidogenic, antioxidant, and anti-inflammatory properties. Understanding these processes could lead to precision clinical approaches and novel strategies for managing and preventing PD.

U2 - 10.1016/j.bbadis.2025.167862

DO - 10.1016/j.bbadis.2025.167862

M3 - Review

C2 - 40254265

SN - 0925-4439

SP - 167862

JO - B B A - Molecular Basis of Disease

JF - B B A - Molecular Basis of Disease

ER -

Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids

Abstract

Access to Document

Fingerprint

Cite this