Parental Prepuberty Overweight and Offspring Lung Function

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DOI

  • Marianne Lønnebotn, University of Bergen, Haukeland University Hospital, Bergen, Norway, Norway
  • Lucia Calciano, University of Verona, Italy
  • Ane Johannessen, University of Bergen, Norway
  • Deborah L. Jarvis, Imperial College London, United Kingdom
  • Michael J. Abramson, Monash University, Australia
  • Bryndís Benediktsdóttir, University of Iceland, Iceland
  • Lennart Bråbäck, Umeå University, Sweden
  • Karl A. Franklin, Umeå University, Sweden
  • Raúl Godoy, University of Castilla-La Mancha, Spain
  • Mathias Holm, University of Gothenburg, Sweden
  • Christer Janson, Uppsala University, Sweden
  • Nils O. Jõgi, University of Bergen, Norway
  • Jorunn Kirkeleit, University of Bergen, Norway
  • Andrei Malinovschi, Uppsala University, Sweden
  • Antonio Pereira-Vega, Juan Ramón Jiménez University Hospital, Spain
  • Vivi Schlünssen
  • Shyamali C. Dharmage, Melbourne School of Population and Global Health, Australia
  • Simone Accordini, University of Verona, Italy
  • Francisco Gómez Real, University of Bergen, Haukeland University Hospital, Bergen, Norway
  • Cecilie Svanes, University of Bergen, Haukeland University Hospital, Bergen, Norway, Norway

In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents’ overweight on adult offspring’s lung function within the paternal and maternal lines. We included 929 offspring (aged 18–54, 54% daughters) of 308 fathers and 388 mothers (aged 40–66). Counterfactual-based multi-group mediation analyses by offspring’s sex (potential moderator) were used, with offspring’s prepubertal overweight and/or adult height as potential mediators. Unknown confounding was addressed by simulation analyses. Fathers’ overweight before puberty had a negative indirect effect, mediated through sons’ height, on sons’ forced expiratory volume in one second (FEV1 ) (beta (95% CI): −144 (−272, −23) mL) and forced vital capacity (FVC) (beta (95% CI): −210 (−380, −34) mL), and a negative direct effect on sons’ FVC (beta (95% CI): −262 (−501, −9) mL); statistically significant effects on FEV1 /FVC were not observed. Mothers’ overweight before puberty had neither direct nor indirect effects on offspring’s lung function. Fathers’ overweight starting before puberty appears to cause lower FEV1 and FVC in their future sons. The effects were partly mediated through sons’ adult height but not through sons’ prepubertal overweight.

Original languageEnglish
Article number1506
JournalNutrients
Volume14
Issue7
Number of pages15
ISSN2072-6643
DOIs
Publication statusPublished - 1 Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

    Research areas

  • causal inference, counterfactual-based mediation analysis, ECRHS, father/paternal/male/men, intergenerational, lung function, nutrition, overweight, prepuberty, RHINE, RHINESSA

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