Department of Economics and Business Economics

Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort

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Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders : Findings From the Danish Birth Cohort. / Janecka, Magdalena; Hansen, Stefan N; Modabbernia, Amirhossein; Browne, Heidi A; Buxbaum, Joseph D; Schendel, Diana E; Reichenberg, Abraham; Parner, Erik T; Grice, Dorothy E.

In: Journal of the American Academy of Child and Adolescent Psychiatry, 27.02.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Janecka, M, Hansen, SN, Modabbernia, A, Browne, HA, Buxbaum, JD, Schendel, DE, Reichenberg, A, Parner, ET & Grice, DE 2019, 'Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort' Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.09.447

APA

Janecka, M., Hansen, S. N., Modabbernia, A., Browne, H. A., Buxbaum, J. D., Schendel, D. E., ... Grice, D. E. (2019). Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.09.447

CBE

Janecka M, Hansen SN, Modabbernia A, Browne HA, Buxbaum JD, Schendel DE, Reichenberg A, Parner ET, Grice DE. 2019. Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.09.447

MLA

Vancouver

Author

Janecka, Magdalena ; Hansen, Stefan N ; Modabbernia, Amirhossein ; Browne, Heidi A ; Buxbaum, Joseph D ; Schendel, Diana E ; Reichenberg, Abraham ; Parner, Erik T ; Grice, Dorothy E. / Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders : Findings From the Danish Birth Cohort. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2019.

Bibtex

@article{848492c258f2480e84e14ad147383573,
title = "Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort",
abstract = "OBJECTIVE: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. We used a population-based cohort to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD) and Tourette syndrome/chronic tic disorder (TS/CT).METHOD: Our study cohort included all singleton births in Denmark between 1980 and 2007 with full information on parental ages (N=1,490,745), followed through December 31, 2013. Cases of ASD, ADHD, OCD and TS/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time.RESULTS: Younger parental age was significantly associated with increased estimates of risk for ADHD and TS/CT, while older parental age was associated with ASD and OCD. Except for OCD, we did not observe any evidence for differential effects of parental ages on male vs. female offspring.CONCLUSION: We provide novel evidence for the association between age at parenthood and TS/CT and OCD, and show for the first time in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. Our results are consistent with a model of both shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.",
author = "Magdalena Janecka and Hansen, {Stefan N} and Amirhossein Modabbernia and Browne, {Heidi A} and Buxbaum, {Joseph D} and Schendel, {Diana E} and Abraham Reichenberg and Parner, {Erik T} and Grice, {Dorothy E}",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "2",
day = "27",
doi = "10.1016/j.jaac.2018.09.447",
language = "English",
journal = "American Academy of Child and Adolescent Psychiatry. Journal",
issn = "0890-8567",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders

T2 - Findings From the Danish Birth Cohort

AU - Janecka, Magdalena

AU - Hansen, Stefan N

AU - Modabbernia, Amirhossein

AU - Browne, Heidi A

AU - Buxbaum, Joseph D

AU - Schendel, Diana E

AU - Reichenberg, Abraham

AU - Parner, Erik T

AU - Grice, Dorothy E

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/2/27

Y1 - 2019/2/27

N2 - OBJECTIVE: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. We used a population-based cohort to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD) and Tourette syndrome/chronic tic disorder (TS/CT).METHOD: Our study cohort included all singleton births in Denmark between 1980 and 2007 with full information on parental ages (N=1,490,745), followed through December 31, 2013. Cases of ASD, ADHD, OCD and TS/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time.RESULTS: Younger parental age was significantly associated with increased estimates of risk for ADHD and TS/CT, while older parental age was associated with ASD and OCD. Except for OCD, we did not observe any evidence for differential effects of parental ages on male vs. female offspring.CONCLUSION: We provide novel evidence for the association between age at parenthood and TS/CT and OCD, and show for the first time in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. Our results are consistent with a model of both shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.

AB - OBJECTIVE: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. We used a population-based cohort to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD) and Tourette syndrome/chronic tic disorder (TS/CT).METHOD: Our study cohort included all singleton births in Denmark between 1980 and 2007 with full information on parental ages (N=1,490,745), followed through December 31, 2013. Cases of ASD, ADHD, OCD and TS/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time.RESULTS: Younger parental age was significantly associated with increased estimates of risk for ADHD and TS/CT, while older parental age was associated with ASD and OCD. Except for OCD, we did not observe any evidence for differential effects of parental ages on male vs. female offspring.CONCLUSION: We provide novel evidence for the association between age at parenthood and TS/CT and OCD, and show for the first time in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. Our results are consistent with a model of both shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.

U2 - 10.1016/j.jaac.2018.09.447

DO - 10.1016/j.jaac.2018.09.447

M3 - Journal article

JO - American Academy of Child and Adolescent Psychiatry. Journal

JF - American Academy of Child and Adolescent Psychiatry. Journal

SN - 0890-8567

ER -