Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors

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Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors. / Brüggemann, Holger; Jensen, Anders; Nazipi, Seven; Aslan, Hüsnü; Meyer, Rikke Louise; Poehlein, Anja; Brzuszkiewicz, Elzbieta; Al-Zeer, Munir A; Brinkmann, Volker; Söderquist, Bo.

In: Scientific Reports, Vol. 8, No. 1, 266, 10.01.2018.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Brüggemann, H, Jensen, A, Nazipi, S, Aslan, H, Meyer, RL, Poehlein, A, Brzuszkiewicz, E, Al-Zeer, MA, Brinkmann, V & Söderquist, B 2018, 'Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors', Scientific Reports, vol. 8, no. 1, 266. https://doi.org/10.1038/s41598-017-18661-8

APA

Brüggemann, H., Jensen, A., Nazipi, S., Aslan, H., Meyer, R. L., Poehlein, A., Brzuszkiewicz, E., Al-Zeer, M. A., Brinkmann, V., & Söderquist, B. (2018). Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors. Scientific Reports, 8(1), [266]. https://doi.org/10.1038/s41598-017-18661-8

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Author

Brüggemann, Holger ; Jensen, Anders ; Nazipi, Seven ; Aslan, Hüsnü ; Meyer, Rikke Louise ; Poehlein, Anja ; Brzuszkiewicz, Elzbieta ; Al-Zeer, Munir A ; Brinkmann, Volker ; Söderquist, Bo. / Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors. In: Scientific Reports. 2018 ; Vol. 8, No. 1.

Bibtex

@article{f889ea41584a4d0980e4064354a70ac6,
title = "Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors",
abstract = "Finegoldia magna, a Gram-positive anaerobic coccus, is an opportunistic pathogen, associated with medical device-related infections. F. magna is the only described species of the genus Finegoldia. We report the analysis of 17 genomes of Finegoldia isolates. Phylogenomic analyses showed that the Finegoldia population can be divided into two distinct clades, with an average nucleotide identity of 90.7%. One clade contains strains of F. magna, whereas the other clade includes more heterogeneous strains, hereafter tentatively named {"}Finegoldia nericia{"}. The latter species appears to be more abundant in the human microbiome. Surface structure differences between strains of F. magna and {"}F. nericia{"} were detected by microscopy. Strain-specific heterogeneity is high and previously identified host-interacting factors are present only in subsets of {"}F. nericia{"} and F. magna strains. However, all genomes encode multiple host factor-binding proteins such as albumin-, collagen-, and immunoglobulin-binding proteins, and two to four copies of CAMP (Christie-Atkins-Munch-Petersen) factors; in accordance, most strains show a positive CAMP reaction for co-hemolysis. Our work sheds new light of the genus Finegoldia and its ability to bind host components. Future research should explore if the genomic differences identified here affect the potential of different Finegoldia species and strains to cause opportunistic infections.",
keywords = "Journal Article",
author = "Holger Br{\"u}ggemann and Anders Jensen and Seven Nazipi and H{\"u}sn{\"u} Aslan and Meyer, {Rikke Louise} and Anja Poehlein and Elzbieta Brzuszkiewicz and Al-Zeer, {Munir A} and Volker Brinkmann and Bo S{\"o}derquist",
year = "2018",
month = jan,
day = "10",
doi = "10.1038/s41598-017-18661-8",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors

AU - Brüggemann, Holger

AU - Jensen, Anders

AU - Nazipi, Seven

AU - Aslan, Hüsnü

AU - Meyer, Rikke Louise

AU - Poehlein, Anja

AU - Brzuszkiewicz, Elzbieta

AU - Al-Zeer, Munir A

AU - Brinkmann, Volker

AU - Söderquist, Bo

PY - 2018/1/10

Y1 - 2018/1/10

N2 - Finegoldia magna, a Gram-positive anaerobic coccus, is an opportunistic pathogen, associated with medical device-related infections. F. magna is the only described species of the genus Finegoldia. We report the analysis of 17 genomes of Finegoldia isolates. Phylogenomic analyses showed that the Finegoldia population can be divided into two distinct clades, with an average nucleotide identity of 90.7%. One clade contains strains of F. magna, whereas the other clade includes more heterogeneous strains, hereafter tentatively named "Finegoldia nericia". The latter species appears to be more abundant in the human microbiome. Surface structure differences between strains of F. magna and "F. nericia" were detected by microscopy. Strain-specific heterogeneity is high and previously identified host-interacting factors are present only in subsets of "F. nericia" and F. magna strains. However, all genomes encode multiple host factor-binding proteins such as albumin-, collagen-, and immunoglobulin-binding proteins, and two to four copies of CAMP (Christie-Atkins-Munch-Petersen) factors; in accordance, most strains show a positive CAMP reaction for co-hemolysis. Our work sheds new light of the genus Finegoldia and its ability to bind host components. Future research should explore if the genomic differences identified here affect the potential of different Finegoldia species and strains to cause opportunistic infections.

AB - Finegoldia magna, a Gram-positive anaerobic coccus, is an opportunistic pathogen, associated with medical device-related infections. F. magna is the only described species of the genus Finegoldia. We report the analysis of 17 genomes of Finegoldia isolates. Phylogenomic analyses showed that the Finegoldia population can be divided into two distinct clades, with an average nucleotide identity of 90.7%. One clade contains strains of F. magna, whereas the other clade includes more heterogeneous strains, hereafter tentatively named "Finegoldia nericia". The latter species appears to be more abundant in the human microbiome. Surface structure differences between strains of F. magna and "F. nericia" were detected by microscopy. Strain-specific heterogeneity is high and previously identified host-interacting factors are present only in subsets of "F. nericia" and F. magna strains. However, all genomes encode multiple host factor-binding proteins such as albumin-, collagen-, and immunoglobulin-binding proteins, and two to four copies of CAMP (Christie-Atkins-Munch-Petersen) factors; in accordance, most strains show a positive CAMP reaction for co-hemolysis. Our work sheds new light of the genus Finegoldia and its ability to bind host components. Future research should explore if the genomic differences identified here affect the potential of different Finegoldia species and strains to cause opportunistic infections.

KW - Journal Article

U2 - 10.1038/s41598-017-18661-8

DO - 10.1038/s41598-017-18661-8

M3 - Journal article

C2 - 29321635

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 266

ER -