Palladium-Catalyzed Synthesis of Aromatic Carboxylic Acids with Silacarboxylic Acids

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Aryl iodides and bromides were easily converted to their corresponding aromatic carboxylic acids via a Pd-catalyzed carbonylation reaction using silacarboxylic acids as an in situ source of carbon monoxide. The reaction conditions were compatible with a wide range of functional groups, and with the aryl iodides, the carbonylation was complete within minutes. The method was adapted to the double and selective isotope labeling of tamibarotene.
Original languageEnglish
JournalOrganic Letters
Volume15
Issue6
Pages (from-to)1378-1381
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2013

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