Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides using near stoichiometric carbon monoxide

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  • Karoline T. Neumann
  • Simon R. Laursen, Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark
  • Anders T. Lindhardt, Interdisciplinary Nanoscience Center (INANO), Department of Engineering, Aarhus University, Denmark
  • Benny Bang-Andersen, Lundbeck Research Denmark, Denmark
  • Troels Skrydstrup
A general procedure for the palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides is reported, using near stoichiometric amounts of carbon monoxide. The method allows a broad substrate scope in moderate to excellent yields. The formed alkynone motive serves as a platform for synthesis of various heterocyclic structures, including pyrimidines. Furthermore, the presented strategy allows effective 13C labeling.
Original languageEnglish
JournalOrganic Letters
Volume16
Issue8
Pages (from-to)2216-2219
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 18 Apr 2014

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