Palladium-Catalyzed Carbonylation of Aryl Bromides with N-Substituted Cyanamides

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  • Zhong Lian, Denmark
  • Stig D. Friis, Denmark
  • Anders T. Lindhardt, Denmark
  • Troels Skrydstrup
The palladium(0)-catalyzed three-component coupling reaction of aryl bromides, carbon monoxide, and N-alkyl cyan­amides has been developed employing a two-chamber system with ex situ generation of carbon monoxide from a silacarboxylic acid. The reactions proceeded well and were complete with a reaction time of only five hours leading to the corresponding N-alkyl cyanamides in good yields. The methodology was further extended to 13C isotope labeling of the carbonyl group through the use of a 13CO produced from the corresponding 13C-labeled version of the sila­carboxylic acid.
Original languageEnglish
JournalSYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Publication statusPublished - 2014

    Research areas

  • aminocarbonylation, isotope labeling, multicomponent reaction, palladium, transition-metal catalysis

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