Aarhus University Seal

Palladium Catalyzed Carbonylative Coupling of Alkyl Boron Reagents with Bromodifluoroacetamides

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • Hongfei Yin, Aarhus University
  • ,
  • Jakob J. Kumke
  • ,
  • Katrine Domino, Aarhus University
  • ,
  • Troels Skrydstrup

A catalytic protocol for the preparation of α,α-difluoro-β-alkyl-β-ketoamides is developed employing a Pd-mediated carbonylative Suzuki coupling between alkylboron reagents and bromodifluoroacetamides with COgen as the CO source. The reaction reveals good functional group tolerance providing a broad selection of α,α-difluoro-β-alkyl-β-ketoamides in moderate to good yields, which represent useful precursors for further synthetic manipulation. Finally, the methodology is amenable to 13C-isotope labeling at the ketone carbon applying 13C-COgen.

Original languageEnglish
JournalACS Catalysis
Pages (from-to)3853-3858
Number of pages6
Publication statusPublished - 4 May 2018

    Research areas

  • alkyl substrates, carbon-13 isotope-labeling, carbonylative Suzuki, fluoride, palladium catalysis

See relations at Aarhus University Citationformats

ID: 128093354