Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles

Johannes Schranck; Mia Burhardt; Christoph Bornschein; Helfried Neumann; Troels Skrydstrup; Matthias Beller

doi:10.1002/chem.201402893

Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles

Johannes Schranck, Mia Burhardt, Christoph Bornschein, Helfried Neumann, Troels Skrydstrup, Matthias Beller

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.

Original language	English
Journal	Chemistry: A European Journal
Volume	20
Issue	31
Pages (from-to)	9534-8
Number of pages	5
ISSN	0947-6539
DOIs	https://doi.org/10.1002/chem.201402893
Publication status	Published - 28 Jul 2014

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10.1002/chem.201402893

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title = "Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles",

abstract = "A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.",

author = "Johannes Schranck and Mia Burhardt and Christoph Bornschein and Helfried Neumann and Troels Skrydstrup and Matthias Beller",

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T1 - Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles

AU - Schranck, Johannes

AU - Burhardt, Mia

AU - Bornschein, Christoph

AU - Neumann, Helfried

AU - Skrydstrup, Troels

AU - Beller, Matthias

PY - 2014/7/28

Y1 - 2014/7/28

N2 - A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.

AB - A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.

U2 - 10.1002/chem.201402893

DO - 10.1002/chem.201402893

M3 - Journal article

C2 - 24986673

SN - 0947-6539

VL - 20

SP - 9534

EP - 9538

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

IS - 31

ER -

Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles

Abstract

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