TY - JOUR
T1 - Painful and non-painful diabetic polyneuropathy
T2 - Clinical characteristics and diagnostic issues
AU - Gylfadottir, Sandra Sif
AU - Weeracharoenkul, Danita
AU - Andersen, Signe Toft
AU - Niruthisard, Supranee
AU - Suwanwalaikorn, Sompongse
AU - Jensen, Troels Staehelin
PY - 2019/9
Y1 - 2019/9
N2 - Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non-painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non-painful DN exists. Hence, a hierarchical classification has been developed categorizing the probability of the diagnosis into: possible, probable or definite, based on the clinical presentation of symptoms and signs. Pain is a warning signal of tissue damage, and non-painful DN therefore represents a clinical and diagnostic challenge because it often goes unnoticed until irreversible nerve damage has occurred. Simple clinical tests seem to be the best for evaluation of DN in the general care for diabetes. Screening programs at regular intervals might be the most optimal strategy for early detection and interventions to possibly prevent further neuronal damage and to lower the economic burden of this complication.
AB - Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non-painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non-painful DN exists. Hence, a hierarchical classification has been developed categorizing the probability of the diagnosis into: possible, probable or definite, based on the clinical presentation of symptoms and signs. Pain is a warning signal of tissue damage, and non-painful DN therefore represents a clinical and diagnostic challenge because it often goes unnoticed until irreversible nerve damage has occurred. Simple clinical tests seem to be the best for evaluation of DN in the general care for diabetes. Screening programs at regular intervals might be the most optimal strategy for early detection and interventions to possibly prevent further neuronal damage and to lower the economic burden of this complication.
KW - Clinical characteristics
KW - Diabetic neuropathy
KW - Diagnosis
KW - CORNEAL CONFOCAL MICROSCOPY
KW - NEUROPATHIC PAIN
KW - RISK-FACTORS
KW - PERIPHERAL NEUROPATHY
KW - GRADING SYSTEM
KW - FOOT CARE
KW - PREVALENCE
KW - MECHANISMS
KW - COMPLICATIONS
KW - SEVERITY
UR - http://www.scopus.com/inward/record.url?scp=85071703777&partnerID=8YFLogxK
U2 - 10.1111/jdi.13105
DO - 10.1111/jdi.13105
M3 - Review
C2 - 31222961
SN - 2040-1116
VL - 10
SP - 1148
EP - 1157
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 5
ER -