P4-ATPases: how an old dog learnt new tricks — structure and mechanism of lipid flippases

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P4-ATPases : how an old dog learnt new tricks — structure and mechanism of lipid flippases. / Lyons, Joseph A.; Timcenko, Milena; Dieudonné, Thibaud; Lenoir, Guillaume; Nissen, Poul.

In: Current Opinion in Structural Biology, Vol. 63, 08.2020, p. 65-73.

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@article{ebd42d0c13c146188ff21235a18bab78,
title = "P4-ATPases: how an old dog learnt new tricks — structure and mechanism of lipid flippases",
abstract = "Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.",
author = "Lyons, {Joseph A.} and Milena Timcenko and Thibaud Dieudonn{\'e} and Guillaume Lenoir and Poul Nissen",
year = "2020",
month = aug,
doi = "10.1016/j.sbi.2020.04.001",
language = "English",
volume = "63",
pages = "65--73",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - P4-ATPases

T2 - how an old dog learnt new tricks — structure and mechanism of lipid flippases

AU - Lyons, Joseph A.

AU - Timcenko, Milena

AU - Dieudonné, Thibaud

AU - Lenoir, Guillaume

AU - Nissen, Poul

PY - 2020/8

Y1 - 2020/8

N2 - Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.

AB - Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.

UR - http://www.scopus.com/inward/record.url?scp=85085619523&partnerID=8YFLogxK

U2 - 10.1016/j.sbi.2020.04.001

DO - 10.1016/j.sbi.2020.04.001

M3 - Review

C2 - 32492637

AN - SCOPUS:85085619523

VL - 63

SP - 65

EP - 73

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

ER -