Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
P4-ATPases : how an old dog learnt new tricks — structure and mechanism of lipid flippases. / Lyons, Joseph A.; Timcenko, Milena; Dieudonné, Thibaud; Lenoir, Guillaume; Nissen, Poul.
In: Current Opinion in Structural Biology, Vol. 63, 08.2020, p. 65-73.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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TY - JOUR
T1 - P4-ATPases
T2 - how an old dog learnt new tricks — structure and mechanism of lipid flippases
AU - Lyons, Joseph A.
AU - Timcenko, Milena
AU - Dieudonné, Thibaud
AU - Lenoir, Guillaume
AU - Nissen, Poul
PY - 2020/8
Y1 - 2020/8
N2 - Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.
AB - Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.
UR - http://www.scopus.com/inward/record.url?scp=85085619523&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2020.04.001
DO - 10.1016/j.sbi.2020.04.001
M3 - Review
C2 - 32492637
AN - SCOPUS:85085619523
VL - 63
SP - 65
EP - 73
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
ER -