P2X7 Receptor Signaling in Stress and Depression

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Standard

P2X7 Receptor Signaling in Stress and Depression. / Ribeiro, Deidiane Elisa; Roncalho, Aline Lulho; Glaser, Talita; Ulrich, Henning; Wegener, Gregers; Joca, Sâmia.

In: International Journal of Molecular Sciences, Vol. 20, No. 11, 06.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Ribeiro, DE, Roncalho, AL, Glaser, T, Ulrich, H, Wegener, G & Joca, S 2019, 'P2X7 Receptor Signaling in Stress and Depression', International Journal of Molecular Sciences, vol. 20, no. 11. https://doi.org/10.3390/ijms20112778

APA

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019). P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences, 20(11). https://doi.org/10.3390/ijms20112778

CBE

Ribeiro DE, Roncalho AL, Glaser T, Ulrich H, Wegener G, Joca S. 2019. P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences. 20(11). https://doi.org/10.3390/ijms20112778

MLA

Ribeiro, Deidiane Elisa et al. "P2X7 Receptor Signaling in Stress and Depression". International Journal of Molecular Sciences. 2019. 20(11). https://doi.org/10.3390/ijms20112778

Vancouver

Ribeiro DE, Roncalho AL, Glaser T, Ulrich H, Wegener G, Joca S. P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences. 2019 Jun;20(11). https://doi.org/10.3390/ijms20112778

Author

Ribeiro, Deidiane Elisa ; Roncalho, Aline Lulho ; Glaser, Talita ; Ulrich, Henning ; Wegener, Gregers ; Joca, Sâmia. / P2X7 Receptor Signaling in Stress and Depression. In: International Journal of Molecular Sciences. 2019 ; Vol. 20, No. 11.

Bibtex

@article{cad759eaabc04afe80c59946b97093ef,
title = "P2X7 Receptor Signaling in Stress and Depression",
abstract = "Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required. Recent studies suggest that adenosine triphosphate (ATP)-mediated signaling through the P2X7 receptor (P2X7R) might play a prominent role in regulating depression-related pathology, such as synaptic plasticity, neuronal degeneration, as well as changes in cognitive and behavioral functions. P2X7R is an ATP-gated cation channel localized in different cell types in the central nervous system (CNS), playing a crucial role in neuron-glia signaling. P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate. Moreover, P2X7R stimulation in microglia modulates the innate immune response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, consistent with the neuroimmune hypothesis of MDD. Importantly, blockade of P2X7R leads to antidepressant-like effects in different animal models, which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans. This review will discuss recent findings linked to the P2X7R involvement in stress and MDD neuropathophysiology, with special emphasis on neurochemical, neuroimmune, and neuroplastic mechanisms.",
author = "Ribeiro, {Deidiane Elisa} and Roncalho, {Aline Lulho} and Talita Glaser and Henning Ulrich and Gregers Wegener and S{\^a}mia Joca",
year = "2019",
month = jun,
doi = "10.3390/ijms20112778",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "11",

}

RIS

TY - JOUR

T1 - P2X7 Receptor Signaling in Stress and Depression

AU - Ribeiro, Deidiane Elisa

AU - Roncalho, Aline Lulho

AU - Glaser, Talita

AU - Ulrich, Henning

AU - Wegener, Gregers

AU - Joca, Sâmia

PY - 2019/6

Y1 - 2019/6

N2 - Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required. Recent studies suggest that adenosine triphosphate (ATP)-mediated signaling through the P2X7 receptor (P2X7R) might play a prominent role in regulating depression-related pathology, such as synaptic plasticity, neuronal degeneration, as well as changes in cognitive and behavioral functions. P2X7R is an ATP-gated cation channel localized in different cell types in the central nervous system (CNS), playing a crucial role in neuron-glia signaling. P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate. Moreover, P2X7R stimulation in microglia modulates the innate immune response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, consistent with the neuroimmune hypothesis of MDD. Importantly, blockade of P2X7R leads to antidepressant-like effects in different animal models, which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans. This review will discuss recent findings linked to the P2X7R involvement in stress and MDD neuropathophysiology, with special emphasis on neurochemical, neuroimmune, and neuroplastic mechanisms.

AB - Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required. Recent studies suggest that adenosine triphosphate (ATP)-mediated signaling through the P2X7 receptor (P2X7R) might play a prominent role in regulating depression-related pathology, such as synaptic plasticity, neuronal degeneration, as well as changes in cognitive and behavioral functions. P2X7R is an ATP-gated cation channel localized in different cell types in the central nervous system (CNS), playing a crucial role in neuron-glia signaling. P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate. Moreover, P2X7R stimulation in microglia modulates the innate immune response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, consistent with the neuroimmune hypothesis of MDD. Importantly, blockade of P2X7R leads to antidepressant-like effects in different animal models, which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans. This review will discuss recent findings linked to the P2X7R involvement in stress and MDD neuropathophysiology, with special emphasis on neurochemical, neuroimmune, and neuroplastic mechanisms.

U2 - 10.3390/ijms20112778

DO - 10.3390/ijms20112778

M3 - Review

C2 - 31174279

VL - 20

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 11

ER -