Oriented Nanoarchitectonics of Bacteriorhodopsin for Enhancing ATP Generation in a FoF1-ATPase-Based Assembly System

Zibo Li, Xia Xu, Fanchen Yu, Jinbo Fei, Qiang Li*, Mingdong Dong*, Junbai Li*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Energy conversion plays an important role in the metabolism of photosynthetic organisms. Improving energy transformation by promoting a proton gradient has been a great challenge for a long time. In the present study, we realize a directional proton migration through the construction of oriented bacteriorhodopsin (BR) microcapsules coated by FoF1-ATPase molecular motors through layer-by-layer (LBL) assembly. The changes in the conformation of BR under illumination lead to proton transfer in a radial direction, which generates a higher proton gradient to drive the synthesis of adenosine triphosphate (ATP) by FoF1-ATPase. Furthermore, to promote the photosynthetic activity, optically matched quantum dots were introduced into the artificial coassembly system of BR and FoF1-ATPase. Such a design creates a new path for the use of light energy.

Original languageEnglish
Article number202116220
JournalAngewandte Chemie - International Edition
Volume61
Issue16
Number of pages6
ISSN1433-7851
DOIs
Publication statusPublished - Apr 2022

Keywords

  • artificial biomimetic system
  • ATP production
  • co-assembly
  • energy conversion
  • proton gradient

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