Opioid binding in DYT1 primary torsion dystonia: An 11C-diprenorphine PET study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Alan L. Whone, Imperial College London, London, UK., Hammersmith Hospital
  • ,
  • Sarah Von Spiczak, Imperial College London, London, UK.
  • ,
  • Mark Edwards, MRC Prion Unit, Institute of Neurology
  • ,
  • Enza Maria Valente, MRC Prion Unit, Institute of Neurology
  • ,
  • Alexander Hammers, Imperial College London, London, UK.
  • ,
  • Kailash P. Bhatia, MRC Prion Unit, Institute of Neurology
  • ,
  • David J. Brooks

The opioid transmitters enkephalin and dynorphin are known to regulate pallidal output and consequently cortical excitability. Indeed, abnormal basal ganglia opioid transmission has been reported in several involuntary movement disorders, including levodopa-induced dyskinesias in Parkinson's disease (PD), tardive dyskinesias/dystonia, Huntington's disease, and Tourette's syndrome. Moreover, a previous 11C-diprenorphine PET study investigating levodopa-induced dyskinesias found reduced opioid receptor availability in PD with but not without dyskinesias. We wished to investigate if a similar alteration in basal ganglia opioid binding was present in DYT1 primary torsion dystonia (PTD). Regional cerebral 11C-diprenorphine binding was investigated in 7 manifesting carriers of the DYT1 gene and 15 age-matched normal controls using a region-of-interest (ROI) approach and statistical parametric mapping (SPM). No difference in regional mean 11C-diprenorphine binding was found between DYT1-PTD and controls, and no correlation between the severity of dystonia and opioid binding was seen. We conclude that aberrant opioid transmission is unlikely to be present in DYT1-PTD and altered opioid transmission is not a common mechanism underlying all disorders of involuntary movement.

Original languageEnglish
JournalMovement Disorders
Volume19
Issue12
Pages (from-to)1498-1503
Number of pages6
ISSN0885-3185
DOIs
Publication statusPublished - 1 Dec 2004
Externally publishedYes

    Research areas

  • C-diprenorphine, Dystonia, DYT1, Opiod

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