On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport

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On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport. / Montigny, Cédric; Lyons, Joseph; Champeil, Philippe; Nissen, Poul; Lenoir, Guillaume.

In: B B A - Molecular and Cell Biology of Lipids, Vol. 1861, No. 8, Part B, 2016.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Montigny, C, Lyons, J, Champeil, P, Nissen, P & Lenoir, G 2016, 'On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport', B B A - Molecular and Cell Biology of Lipids, vol. 1861, no. 8, Part B. https://doi.org/10.1016/j.bbalip.2015.12.020

APA

Montigny, C., Lyons, J., Champeil, P., Nissen, P., & Lenoir, G. (2016). On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport. B B A - Molecular and Cell Biology of Lipids, 1861(8, Part B). https://doi.org/10.1016/j.bbalip.2015.12.020

CBE

Montigny C, Lyons J, Champeil P, Nissen P, Lenoir G. 2016. On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport. B B A - Molecular and Cell Biology of Lipids. 1861(8, Part B). https://doi.org/10.1016/j.bbalip.2015.12.020

MLA

Montigny, Cédric et al. "On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport". B B A - Molecular and Cell Biology of Lipids. 2016. 1861(8, Part B). https://doi.org/10.1016/j.bbalip.2015.12.020

Vancouver

Montigny C, Lyons J, Champeil P, Nissen P, Lenoir G. On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport. B B A - Molecular and Cell Biology of Lipids. 2016;1861(8, Part B). https://doi.org/10.1016/j.bbalip.2015.12.020

Author

Montigny, Cédric ; Lyons, Joseph ; Champeil, Philippe ; Nissen, Poul ; Lenoir, Guillaume. / On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport. In: B B A - Molecular and Cell Biology of Lipids. 2016 ; Vol. 1861, No. 8, Part B.

Bibtex

@article{df4d60e8db6d4497baee8fafa9fb8663,
title = "On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport",
abstract = "Phospholipid flippasesare key regulators of transbilayer lipid asymmetry in eukaryotic cell membranes, critical to many trafficking and signaling pathways. P4-ATPases, in particular, are responsible for the uphill transport of phospholipids from the exoplasmic to the cytosolic leaflet of the plasma membrane, as well as membranes of the late secretory/endocytic pathways, thereby establishing transbilayer asymmetry. Recent studies combining cell biology and biochemical approaches have improved our understanding of the path taken by lipids through P4-ATPases. Additionally, identification of several protein families catalyzing phospholipid 'scrambling', i.e. disruption of phospholipid asymmetry through energy-independent bi-directional phospholipid transport, as well as the recent report of the structure of such a scramblase, opens the way to a deeper characterization of their mechanism of action. Here, we discuss the molecular nature of the mechanism by which lipids may 'flip' across membranes, with an emphasis on active lipid transport catalyzed by P4-ATPases. {"}This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim Levine and Anant K. Menon.{"}",
author = "C{\'e}dric Montigny and Joseph Lyons and Philippe Champeil and Poul Nissen and Guillaume Lenoir",
note = "Copyright {\circledC} 2016. Published by Elsevier B.V.",
year = "2016",
doi = "10.1016/j.bbalip.2015.12.020",
language = "English",
volume = "1861",
journal = "B B A - Molecular and Cell Biology of Lipids",
issn = "1388-1981",
publisher = "Elsevier BV",
number = "8, Part B",

}

RIS

TY - JOUR

T1 - On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport

AU - Montigny, Cédric

AU - Lyons, Joseph

AU - Champeil, Philippe

AU - Nissen, Poul

AU - Lenoir, Guillaume

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016

Y1 - 2016

N2 - Phospholipid flippasesare key regulators of transbilayer lipid asymmetry in eukaryotic cell membranes, critical to many trafficking and signaling pathways. P4-ATPases, in particular, are responsible for the uphill transport of phospholipids from the exoplasmic to the cytosolic leaflet of the plasma membrane, as well as membranes of the late secretory/endocytic pathways, thereby establishing transbilayer asymmetry. Recent studies combining cell biology and biochemical approaches have improved our understanding of the path taken by lipids through P4-ATPases. Additionally, identification of several protein families catalyzing phospholipid 'scrambling', i.e. disruption of phospholipid asymmetry through energy-independent bi-directional phospholipid transport, as well as the recent report of the structure of such a scramblase, opens the way to a deeper characterization of their mechanism of action. Here, we discuss the molecular nature of the mechanism by which lipids may 'flip' across membranes, with an emphasis on active lipid transport catalyzed by P4-ATPases. "This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim Levine and Anant K. Menon."

AB - Phospholipid flippasesare key regulators of transbilayer lipid asymmetry in eukaryotic cell membranes, critical to many trafficking and signaling pathways. P4-ATPases, in particular, are responsible for the uphill transport of phospholipids from the exoplasmic to the cytosolic leaflet of the plasma membrane, as well as membranes of the late secretory/endocytic pathways, thereby establishing transbilayer asymmetry. Recent studies combining cell biology and biochemical approaches have improved our understanding of the path taken by lipids through P4-ATPases. Additionally, identification of several protein families catalyzing phospholipid 'scrambling', i.e. disruption of phospholipid asymmetry through energy-independent bi-directional phospholipid transport, as well as the recent report of the structure of such a scramblase, opens the way to a deeper characterization of their mechanism of action. Here, we discuss the molecular nature of the mechanism by which lipids may 'flip' across membranes, with an emphasis on active lipid transport catalyzed by P4-ATPases. "This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim Levine and Anant K. Menon."

U2 - 10.1016/j.bbalip.2015.12.020

DO - 10.1016/j.bbalip.2015.12.020

M3 - Journal article

C2 - 26747647

VL - 1861

JO - B B A - Molecular and Cell Biology of Lipids

JF - B B A - Molecular and Cell Biology of Lipids

SN - 1388-1981

IS - 8, Part B

ER -