Occupational exposure to epoxy components and risk of dermatitis: A registry-based follow-up study of the wind turbine industry

Alexandra Golabek Christiansen*, Martin Byskov Kinnerup, Ole Carstensen, Mette Sommerlund, Per Axel Clausen, Jakob Hjort Bønløkke, Vivi Schlünssen, Marléne Isaksson, Sigrun Alba Johannesdottir Schmidt, Henrik Albert Kolstad

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

BACKGROUND: Allergic contact allergy and dermatitis are frequently reported among epoxy-exposed workers.

OBJECTIVES: To determine the risk of dermatitis associated with epoxy exposure.

METHODS: We followed 825 epoxy-exposed and 1091 non-exposed blue-collar workers, and 493 white-collar workers of a Danish wind turbine blade factory during 2017-2022 with linked data from national health registers on diagnoses, patch testing, or fillings of prescriptions for topical corticosteroids. Incidence rate ratios of dermatitis or a first-time topical corticosteroid prescription were estimated with Poisson regression using non-exposed blue-collar workers as reference. We similarly estimated incidence rate ratios for the duration of epoxy exposure and current epoxy exposure.

RESULTS: Epoxy-exposed blue-collar workers showed a dermatitis incidence rate of 2.1 per 100 000 person days, a two-fold increased risk of dermatitis and a 20% increased risk of filling a prescription for topical corticosteroids. Incidence rate ratios were higher during early exposure and declined with further exposure for both outcomes. White-collar workers had generally lower risks.

CONCLUSION: We observed an increased risk of dermatitis following epoxy exposure confirming previous case reports and cross-sectional studies emphasizing the need for intensified focus on preventive efforts for this group of workers.

Original languageEnglish
Book seriesContact Dermatitis
Volume90
Issue1
Pages (from-to)32-40
Number of pages9
ISSN1396-6669
DOIs
Publication statusPublished - Jan 2024

Keywords

  • allergic contact dermatitis
  • epidemiology
  • epoxy resin systems
  • occupational
  • Adrenal Cortex Hormones/adverse effects
  • Cross-Sectional Studies
  • Follow-Up Studies
  • Dermatitis, Occupational/epidemiology
  • Humans
  • Occupational Exposure/adverse effects
  • Dermatitis, Allergic Contact/epidemiology
  • Patch Tests/adverse effects
  • Registries
  • Epoxy Resins/adverse effects

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