Nucleophilic fluorination facilitated by a CsF-CaF2 packed bed reactor in continuous flow

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DOI

A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations.

Original languageEnglish
JournalChemical Communications
Volume54
Issue7
Pages (from-to)825-828
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 21 Jan 2018

    Research areas

  • F BOND FORMATION, DRUG DISCOVERY, FLUORIDE SALTS, TRIFLUOROMETHYLATION, CHEMISTRY, REAGENTS, ALUMINA, ION

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