Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. / Krüger, Franziska; Kumar, Vipin; Monge, Pere; Conzelmann, Carina; Smith, Nikaïa; Gothelf, Kurt V.; Tolstrup, Martin; Münch, Jan; Zelikin, Alexander N.

In: Advanced Science, Vol. 6, No. 6, 1802095, 2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Author

Krüger, Franziska ; Kumar, Vipin ; Monge, Pere ; Conzelmann, Carina ; Smith, Nikaïa ; Gothelf, Kurt V. ; Tolstrup, Martin ; Münch, Jan ; Zelikin, Alexander N. / Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. In: Advanced Science. 2019 ; Vol. 6, No. 6.

Bibtex

@article{fa8e25df124d40fab864f439a425108d,
title = "Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues",
abstract = "Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.",
keywords = "antivirals, herpes simplex virus, nucleic acids, nucleoside analogues, prodrugs",
author = "Franziska Kr{\"u}ger and Vipin Kumar and Pere Monge and Carina Conzelmann and Nika{\"i}a Smith and Gothelf, {Kurt V.} and Martin Tolstrup and Jan M{\"u}nch and Zelikin, {Alexander N.}",
year = "2019",
doi = "10.1002/advs.201802095",
language = "English",
volume = "6",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

AU - Krüger, Franziska

AU - Kumar, Vipin

AU - Monge, Pere

AU - Conzelmann, Carina

AU - Smith, Nikaïa

AU - Gothelf, Kurt V.

AU - Tolstrup, Martin

AU - Münch, Jan

AU - Zelikin, Alexander N.

PY - 2019

Y1 - 2019

N2 - Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

AB - Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

KW - antivirals

KW - herpes simplex virus

KW - nucleic acids

KW - nucleoside analogues

KW - prodrugs

UR - http://www.scopus.com/inward/record.url?scp=85060776730&partnerID=8YFLogxK

U2 - 10.1002/advs.201802095

DO - 10.1002/advs.201802095

M3 - Journal article

C2 - 30937274

AN - SCOPUS:85060776730

VL - 6

JO - Advanced Science

JF - Advanced Science

SN - 2198-3844

IS - 6

M1 - 1802095

ER -