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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

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Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

Original languageEnglish
Article number1802095
JournalAdvanced Science
Publication statusPublished - 2019

    Research areas

  • antivirals, herpes simplex virus, nucleic acids, nucleoside analogues, prodrugs

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