Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Franziska Krüger; Vipin Kumar; Pere Monge; Carina Conzelmann; Nikaïa Smith; Kurt V. Gothelf; Martin Tolstrup; Jan Münch; Alexander N. Zelikin

doi:10.1002/advs.201802095

Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Franziska Krüger, Vipin Kumar, Pere Monge, Carina Conzelmann, Nikaïa Smith, Kurt V. Gothelf, Martin Tolstrup, Jan Münch^*, Alexander N. Zelikin

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

Original language	English
Article number	1802095
Journal	Advanced Science
Volume	6
Issue	6
DOIs	https://doi.org/10.1002/advs.201802095
Publication status	Published - 2019

Keywords

antivirals
herpes simplex virus
nucleic acids
nucleoside analogues
prodrugs

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10.1002/advs.201802095

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AU - Krüger, Franziska

AU - Kumar, Vipin

AU - Monge, Pere

AU - Conzelmann, Carina

AU - Smith, Nikaïa

AU - Gothelf, Kurt V.

AU - Tolstrup, Martin

AU - Münch, Jan

AU - Zelikin, Alexander N.

PY - 2019

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AB - Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

KW - antivirals

KW - herpes simplex virus

KW - nucleic acids

KW - nucleoside analogues

KW - prodrugs

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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Abstract

Keywords

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