TY - JOUR
T1 - Novelty-induced memory consolidation is accompanied by increased Agap3 transcription
T2 - a cross-species study
AU - Højgaard, Kristoffer
AU - Szöllősi, Bianka
AU - Henningsen, Kim
AU - Minami, Natsumi
AU - Nakanishi, Nobuhiro
AU - Kaadt, Erik
AU - Tamura, Makoto
AU - Morris, Richard G.M.
AU - Takeuchi, Tomonori
AU - Elfving, Betina
N1 - Publisher Copyright:
© 2023, Min Zhuo, Bong-Kiun Kaang and BioMed central Ltd.
PY - 2023/12
Y1 - 2023/12
N2 - Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cellular memory consolidation. Several genes have been identified to date, however, to fully understand the mechanisms of memory consolidation, additional candidates must be identified. In this cross-species study, we used a contextual novelty-exploration paradigm to identify changes in gene expression in the dorsal hippocampus of both mice and rats. We found that changes in gene expression following contextual novelty varied between the two species, with 9 genes being upregulated in mice and 3 genes in rats. Comparison across species revealed that ArfGAP with a GTPase domain, an ankyrin repeat and PH domain 3 (Agap3) was the only gene being upregulated in both, suggesting a potentially conserved role for Agap3. AGAP3 is known to regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor trafficking in the synapse, which suggests that increased transcription of Agap3 may be involved in maintaining functional plasticity. While we identified several genes affected by contextual novelty exploration, we were unable to fully reverse these changes using SCH 23390, a dopamine D1/D5 receptor antagonist. Further research on the role of AGAP3 in novelty-induced memory consolidation could lead to better understanding of this process and guide future research.
AB - Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cellular memory consolidation. Several genes have been identified to date, however, to fully understand the mechanisms of memory consolidation, additional candidates must be identified. In this cross-species study, we used a contextual novelty-exploration paradigm to identify changes in gene expression in the dorsal hippocampus of both mice and rats. We found that changes in gene expression following contextual novelty varied between the two species, with 9 genes being upregulated in mice and 3 genes in rats. Comparison across species revealed that ArfGAP with a GTPase domain, an ankyrin repeat and PH domain 3 (Agap3) was the only gene being upregulated in both, suggesting a potentially conserved role for Agap3. AGAP3 is known to regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor trafficking in the synapse, which suggests that increased transcription of Agap3 may be involved in maintaining functional plasticity. While we identified several genes affected by contextual novelty exploration, we were unable to fully reverse these changes using SCH 23390, a dopamine D1/D5 receptor antagonist. Further research on the role of AGAP3 in novelty-induced memory consolidation could lead to better understanding of this process and guide future research.
KW - AGAP3
KW - Behavioural tagging
KW - Dopamine
KW - Dopamine receptor antagonist
KW - Hippocampus
KW - Immediate-early gene
KW - Locus coeruleus
KW - Memory consolidation
KW - Novelty
KW - Synaptic tagging and capture hypothesis
UR - http://www.scopus.com/inward/record.url?scp=85172168808&partnerID=8YFLogxK
U2 - 10.1186/s13041-023-01056-4
DO - 10.1186/s13041-023-01056-4
M3 - Journal article
C2 - 37749596
AN - SCOPUS:85172168808
SN - 1756-6606
VL - 16
JO - Molecular Brain
JF - Molecular Brain
IS - 1
M1 - 69
ER -