Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems

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Novelty and Dopaminergic Modulation of Memory Persistence : A Tale of Two Systems. / Duszkiewicz, Adrian J; McNamara, Colin G; Takeuchi, Tomonori; Genzel, Lisa.

In: Trends in Neurosciences, Vol. 42, No. 2, 02.2019, p. 102-114.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Duszkiewicz, AJ, McNamara, CG, Takeuchi, T & Genzel, L 2019, 'Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems', Trends in Neurosciences, vol. 42, no. 2, pp. 102-114. https://doi.org/10.1016/j.tins.2018.10.002

APA

Duszkiewicz, A. J., McNamara, C. G., Takeuchi, T., & Genzel, L. (2019). Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems. Trends in Neurosciences, 42(2), 102-114. https://doi.org/10.1016/j.tins.2018.10.002

CBE

MLA

Vancouver

Duszkiewicz AJ, McNamara CG, Takeuchi T, Genzel L. Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems. Trends in Neurosciences. 2019 Feb;42(2):102-114. https://doi.org/10.1016/j.tins.2018.10.002

Author

Duszkiewicz, Adrian J ; McNamara, Colin G ; Takeuchi, Tomonori ; Genzel, Lisa. / Novelty and Dopaminergic Modulation of Memory Persistence : A Tale of Two Systems. In: Trends in Neurosciences. 2019 ; Vol. 42, No. 2. pp. 102-114.

Bibtex

@article{f4491f070a444d44867e4c06ce6d98c3,
title = "Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems",
abstract = "Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. In this opinion article, we propose that the projections originating from the VTA and the LC belong to two distinct systems that enhance memory of novel events. Novel experiences that share some commonality with past ones ('common novelty') activate the VTA and promote semantic memory formation via systems memory consolidation. By contrast, experiences that bear only a minimal relationship to past experiences ('distinct novelty') activate the LC to trigger strong initial memory consolidation in the hippocampus, resulting in vivid and long-lasting episodic memories.",
author = "Duszkiewicz, {Adrian J} and McNamara, {Colin G} and Tomonori Takeuchi and Lisa Genzel",
note = "Copyright {\circledC} 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = "2",
doi = "10.1016/j.tins.2018.10.002",
language = "English",
volume = "42",
pages = "102--114",
journal = "Trends in Neurosciences",
issn = "0166-2236",
publisher = "Elsevier Ltd. * Trends Journals",
number = "2",

}

RIS

TY - JOUR

T1 - Novelty and Dopaminergic Modulation of Memory Persistence

T2 - A Tale of Two Systems

AU - Duszkiewicz, Adrian J

AU - McNamara, Colin G

AU - Takeuchi, Tomonori

AU - Genzel, Lisa

N1 - Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2019/2

Y1 - 2019/2

N2 - Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. In this opinion article, we propose that the projections originating from the VTA and the LC belong to two distinct systems that enhance memory of novel events. Novel experiences that share some commonality with past ones ('common novelty') activate the VTA and promote semantic memory formation via systems memory consolidation. By contrast, experiences that bear only a minimal relationship to past experiences ('distinct novelty') activate the LC to trigger strong initial memory consolidation in the hippocampus, resulting in vivid and long-lasting episodic memories.

AB - Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. In this opinion article, we propose that the projections originating from the VTA and the LC belong to two distinct systems that enhance memory of novel events. Novel experiences that share some commonality with past ones ('common novelty') activate the VTA and promote semantic memory formation via systems memory consolidation. By contrast, experiences that bear only a minimal relationship to past experiences ('distinct novelty') activate the LC to trigger strong initial memory consolidation in the hippocampus, resulting in vivid and long-lasting episodic memories.

U2 - 10.1016/j.tins.2018.10.002

DO - 10.1016/j.tins.2018.10.002

M3 - Review

VL - 42

SP - 102

EP - 114

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0166-2236

IS - 2

ER -