Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation

Mariam Abdi Noor; Leila Louise Benhassen; Alexander Emil Kaspersen; Marc Gjern Weiss; John Michael Hasenkam; Peter Johansen

doi:10.1007/s12265-023-10393-7

Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation

Mariam Abdi Noor^*, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

An increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0.003) and the A-ring group (p = 0.020) when compared with the native group. Both the Dacron ring and A-ring effectively downsized the aortic annulus diameter. The A-ring also displayed an ability to maintain aortic root distensibility during the cardiac cycle equally to the Dacron ring. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Journal	Journal of Cardiovascular Translational Research
Volume	16
Issue	5
Pages (from-to)	1144-1152
Number of pages	9
ISSN	1937-5387
DOIs	https://doi.org/10.1007/s12265-023-10393-7
Publication status	Published - Oct 2023

Keywords

Annuloplasty
Aortic valve repair
Cardiovascular interventions
Hemodynamics
Polyethylene Terephthalates
Humans
Heart Valve Prosthesis
Aortic Valve Insufficiency
Prosthesis Design
Aortic Valve/diagnostic imaging
Cardiac Valve Annuloplasty/adverse effects

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title = "Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation",

abstract = "An increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0.003) and the A-ring group (p = 0.020) when compared with the native group. Both the Dacron ring and A-ring effectively downsized the aortic annulus diameter. The A-ring also displayed an ability to maintain aortic root distensibility during the cardiac cycle equally to the Dacron ring. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Annuloplasty, Aortic valve repair, Cardiovascular interventions, Hemodynamics, Polyethylene Terephthalates, Humans, Heart Valve Prosthesis, Aortic Valve Insufficiency, Prosthesis Design, Aortic Valve/diagnostic imaging, Cardiac Valve Annuloplasty/adverse effects",

author = "Noor, {Mariam Abdi} and Benhassen, {Leila Louise} and Kaspersen, {Alexander Emil} and Weiss, {Marc Gjern} and Hasenkam, {John Michael} and Peter Johansen",

year = "2023",

month = oct,

doi = "10.1007/s12265-023-10393-7",

language = "English",

volume = "16",

pages = "1144--1152",

journal = "Journal of Cardiovascular Translational Research",

issn = "1937-5387",

publisher = "Springer",

number = "5",

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Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation. / Noor, Mariam Abdi ; Benhassen, Leila Louise ; Kaspersen, Alexander Emil et al.
In: Journal of Cardiovascular Translational Research, Vol. 16, No. 5, 10.2023, p. 1144-1152.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation

AU - Noor, Mariam Abdi

AU - Benhassen, Leila Louise

AU - Kaspersen, Alexander Emil

AU - Weiss, Marc Gjern

AU - Hasenkam, John Michael

AU - Johansen, Peter

PY - 2023/10

Y1 - 2023/10

N2 - An increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0.003) and the A-ring group (p = 0.020) when compared with the native group. Both the Dacron ring and A-ring effectively downsized the aortic annulus diameter. The A-ring also displayed an ability to maintain aortic root distensibility during the cardiac cycle equally to the Dacron ring. Graphical abstract: [Figure not available: see fulltext.]

AB - An increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0.003) and the A-ring group (p = 0.020) when compared with the native group. Both the Dacron ring and A-ring effectively downsized the aortic annulus diameter. The A-ring also displayed an ability to maintain aortic root distensibility during the cardiac cycle equally to the Dacron ring. Graphical abstract: [Figure not available: see fulltext.]

KW - Annuloplasty

KW - Aortic valve repair

KW - Cardiovascular interventions

KW - Hemodynamics

KW - Polyethylene Terephthalates

KW - Humans

KW - Heart Valve Prosthesis

KW - Aortic Valve Insufficiency

KW - Prosthesis Design

KW - Aortic Valve/diagnostic imaging

KW - Cardiac Valve Annuloplasty/adverse effects

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SN - 1937-5387

VL - 16

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JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 5

ER -

Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring—an In Vitro Evaluation

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