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Normative data on cardiovascular autonomic function in Greenlandic Inuit. / Christensen, Marie Mathilde Bjerg; Hansen, Christian Stevns; Fleischer, Jesper; Vistisen, Dorte; Byberg, Stine; Larsen, Trine; Laursen, Jens Christian; Jørgensen, Marit Eika.
In: BMJ open diabetes research & care, Vol. 9, No. 1, e002121, 01.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Normative data on cardiovascular autonomic function in Greenlandic Inuit
AU - Christensen, Marie Mathilde Bjerg
AU - Hansen, Christian Stevns
AU - Fleischer, Jesper
AU - Vistisen, Dorte
AU - Byberg, Stine
AU - Larsen, Trine
AU - Laursen, Jens Christian
AU - Jørgensen, Marit Eika
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2021.
PY - 2021/1
Y1 - 2021/1
N2 - Introduction Diabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit. Research design and methods In this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex. Results Based on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found. Conclusions The general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function.
AB - Introduction Diabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit. Research design and methods In this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex. Results Based on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found. Conclusions The general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function.
KW - diabetes complications
KW - diabetic neuropathies
KW - heart rate variability
KW - indigenous peoples
UR - http://www.scopus.com/inward/record.url?scp=85116593867&partnerID=8YFLogxK
U2 - 10.1136/bmjdrc-2021-002121
DO - 10.1136/bmjdrc-2021-002121
M3 - Journal article
C2 - 34598933
AN - SCOPUS:85116593867
VL - 9
JO - BMJ open diabetes research & care
JF - BMJ open diabetes research & care
SN - 2052-4897
IS - 1
M1 - e002121
ER -