Normative data on cardiovascular autonomic function in Greenlandic Inuit

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Normative data on cardiovascular autonomic function in Greenlandic Inuit. / Christensen, Marie Mathilde Bjerg; Hansen, Christian Stevns; Fleischer, Jesper; Vistisen, Dorte; Byberg, Stine; Larsen, Trine; Laursen, Jens Christian; Jørgensen, Marit Eika.

In: BMJ open diabetes research & care, Vol. 9, No. 1, e002121, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Christensen, MMB, Hansen, CS, Fleischer, J, Vistisen, D, Byberg, S, Larsen, T, Laursen, JC & Jørgensen, ME 2021, 'Normative data on cardiovascular autonomic function in Greenlandic Inuit', BMJ open diabetes research & care, vol. 9, no. 1, e002121. https://doi.org/10.1136/bmjdrc-2021-002121

APA

Christensen, M. M. B., Hansen, C. S., Fleischer, J., Vistisen, D., Byberg, S., Larsen, T., Laursen, J. C., & Jørgensen, M. E. (2021). Normative data on cardiovascular autonomic function in Greenlandic Inuit. BMJ open diabetes research & care, 9(1), [e002121]. https://doi.org/10.1136/bmjdrc-2021-002121

CBE

Christensen MMB, Hansen CS, Fleischer J, Vistisen D, Byberg S, Larsen T, Laursen JC, Jørgensen ME. 2021. Normative data on cardiovascular autonomic function in Greenlandic Inuit. BMJ open diabetes research & care. 9(1):Article e002121. https://doi.org/10.1136/bmjdrc-2021-002121

MLA

Vancouver

Christensen MMB, Hansen CS, Fleischer J, Vistisen D, Byberg S, Larsen T et al. Normative data on cardiovascular autonomic function in Greenlandic Inuit. BMJ open diabetes research & care. 2021 Jan;9(1). e002121. https://doi.org/10.1136/bmjdrc-2021-002121

Author

Christensen, Marie Mathilde Bjerg ; Hansen, Christian Stevns ; Fleischer, Jesper ; Vistisen, Dorte ; Byberg, Stine ; Larsen, Trine ; Laursen, Jens Christian ; Jørgensen, Marit Eika. / Normative data on cardiovascular autonomic function in Greenlandic Inuit. In: BMJ open diabetes research & care. 2021 ; Vol. 9, No. 1.

Bibtex

@article{bb776b21efe1480f8c48a8b2e46b6e0c,
title = "Normative data on cardiovascular autonomic function in Greenlandic Inuit",
abstract = "Introduction Diabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit. Research design and methods In this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex. Results Based on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found. Conclusions The general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function. ",
keywords = "diabetes complications, diabetic neuropathies, heart rate variability, indigenous peoples",
author = "Christensen, {Marie Mathilde Bjerg} and Hansen, {Christian Stevns} and Jesper Fleischer and Dorte Vistisen and Stine Byberg and Trine Larsen and Laursen, {Jens Christian} and J{\o}rgensen, {Marit Eika}",
note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021.",
year = "2021",
month = jan,
doi = "10.1136/bmjdrc-2021-002121",
language = "English",
volume = "9",
journal = "BMJ open diabetes research & care",
issn = "2052-4897",
publisher = "BMJ Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Normative data on cardiovascular autonomic function in Greenlandic Inuit

AU - Christensen, Marie Mathilde Bjerg

AU - Hansen, Christian Stevns

AU - Fleischer, Jesper

AU - Vistisen, Dorte

AU - Byberg, Stine

AU - Larsen, Trine

AU - Laursen, Jens Christian

AU - Jørgensen, Marit Eika

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2021.

PY - 2021/1

Y1 - 2021/1

N2 - Introduction Diabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit. Research design and methods In this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex. Results Based on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found. Conclusions The general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function.

AB - Introduction Diabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit. Research design and methods In this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex. Results Based on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found. Conclusions The general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function.

KW - diabetes complications

KW - diabetic neuropathies

KW - heart rate variability

KW - indigenous peoples

UR - http://www.scopus.com/inward/record.url?scp=85116593867&partnerID=8YFLogxK

U2 - 10.1136/bmjdrc-2021-002121

DO - 10.1136/bmjdrc-2021-002121

M3 - Journal article

C2 - 34598933

AN - SCOPUS:85116593867

VL - 9

JO - BMJ open diabetes research & care

JF - BMJ open diabetes research & care

SN - 2052-4897

IS - 1

M1 - e002121

ER -