Nordic OCD & Related Disorders Consortium: Rationale, design, and methods

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DOI

  • David Mataix-Cols, Karolinska Institutet, Stockholm Health Care Services
  • ,
  • Bjarne Hansen, University of Bergen, Department of Clinical Psychology
  • ,
  • Manuel Mattheisen
  • Elinor K. Karlsson, Broad Institute, University of Massachusetts Medical School
  • ,
  • Anjené M. Addington, National Institutes of Health
  • ,
  • Julia Boberg, Karolinska Institutet, Stockholm Health Care Services
  • ,
  • Diana R. Djurfeldt, Karolinska Institutet, Stockholm Health Care Services
  • ,
  • Matthew Halvorsen, University of North Carolina
  • ,
  • Paul Lichtenstein, Karolinska Institutet
  • ,
  • Stian Solem, University of Bergen, Norwegian University of Science and Technology
  • ,
  • Kerstin Lindblad-Toh, Broad Institute, Uppsala University
  • ,
  • Jan Haavik, University of Bergen
  • ,
  • Gerd Kvale, University of Bergen
  • ,
  • Christian Rück, Karolinska Institutet, Stockholm Health Care Services
  • ,
  • James J. Crowley, Karolinska Institutet, University of North Carolina
  • ,
  • Nordic OCD and Related Disorders Consortium (NORDiC)

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is unknown and treatment outcomes could be improved if biological targets could be identified. Unfortunately, genetic findings for OCD are lagging behind other psychiatric disorders. Thus, there is a pressing need to understand the causal mechanisms implicated in OCD in order to improve clinical outcomes and to reduce morbidity and societal costs. Specifically, there is a need for a large-scale, etiologically informative genetic study integrating genetic and environmental factors that presumably interact to cause the condition. The Nordic countries provide fertile ground for such a study, given their detailed population registers, national healthcare systems and active specialist clinics for OCD. We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases. Our specific aims are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD. This article describes and discusses the rationale, design, and methodology of NORDiC, including details on clinical measures and planned genomic analyses.

Original languageEnglish
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume183
Issue1
Pages (from-to)38-50
Number of pages13
ISSN1552-4841
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • Denmark, genetic, GWAS, Norway, OCD, Sweden

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