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Nontoxic silicene photothermal agents with high near-infrared absorption for disassembly of Alzheimer's amyloid‑β fibrils

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Xiaoteng Liang, Hebei University of Technology, Shandong University
  • ,
  • Yin Wang
  • ,
  • Jie Song, Hebei University of Technology, Shandong University
  • ,
  • Dan Xia, Hebei University of Technology
  • ,
  • Qiang Li, Shandong University
  • ,
  • Mingdong Dong

The disassembly and eliminating the amyloid-β (Aβ) aggregates has become an effective way to treat Alzheimer's disease (AD). Herein, for the first time, the near-infrared (NIR) activated silicene nanosheets (SNSs) have been identified as an effective nontoxic photothermal conversion agent for irreversibly disassembly of the Aβ33–42 aggregates. The SNSs synthesized by a combination of mild oxidation method and liquid exfoliation method possess good biocompatibility and biodegradability, and high near-infrared photothermal conversion capabilities. Under NIR light, the SNSs could disassemble the large and dense Aβ33–42 mature fibrils into short fibrils and even form thin films, leading to the degradation rate of 96.47%. The circular dichroism spectrum, fluorescent spectra, and nanostructure were analyzed to monitor the photothermal degradation of mature Aβ33–42 fibrils for elaborating the mechanism beneath. This study might provide a clue for developing potential therapeutic strategy for AD and related neurodegenerative diseases.

Original languageEnglish
Article number112575
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - Aug 2022

Bibliographical note

Publisher Copyright:
© 2022

    Research areas

  • Amyloid-β disassembly, Atomic force microscopy, Photothermal degradation, Silicene nanosheets

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