Noninvasive Stimulation of the Human Brain: Activation of Multiple Cortical Circuits

Vincenzo Di Lazzaro; John Rothwell; Marco Capogna

doi:10.1177/1073858417717660

Noninvasive Stimulation of the Human Brain: Activation of Multiple Cortical Circuits

Vincenzo Di Lazzaro, John Rothwell, Marco Capogna

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Noninvasive brain stimulation methods, such as transcranial electric stimulation and transcranial magnetic stimulation are widely used tools for both basic research and clinical applications. However, the cortical circuits underlying their effects are poorly defined. Here we review the current knowledge based on data mostly coming from experiments performed on human subjects, and also to a lesser extent on rodent or primate models. The data suggest that multiple mechanisms are likely to be involved, such as the direct activation of layer V pyramidal neurons, but also of different types of GABAergic interneurons. In this regard, we propose a key role for a specific type of interneuron known as neurogliaform cell.

Original language	English
Journal	Neuroscientist
Volume	24
Issue	3
Pages (from-to)	246-260
Number of pages	15
ISSN	1073-8584
DOIs	https://doi.org/10.1177/1073858417717660
Publication status	Published - Jun 2018

Keywords

Journal Article
neurogliaform cell
transcranial electrical stimulation
cortical pyramidal neuron
transcranial magnetic stimulation
cortical interneuron
Neurons/physiology
Humans
Brain/physiology
Transcranial Magnetic Stimulation
Transcranial Direct Current Stimulation
Animals
Neural Pathways/physiology

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title = "Noninvasive Stimulation of the Human Brain: Activation of Multiple Cortical Circuits",

abstract = "Noninvasive brain stimulation methods, such as transcranial electric stimulation and transcranial magnetic stimulation are widely used tools for both basic research and clinical applications. However, the cortical circuits underlying their effects are poorly defined. Here we review the current knowledge based on data mostly coming from experiments performed on human subjects, and also to a lesser extent on rodent or primate models. The data suggest that multiple mechanisms are likely to be involved, such as the direct activation of layer V pyramidal neurons, but also of different types of GABAergic interneurons. In this regard, we propose a key role for a specific type of interneuron known as neurogliaform cell.",

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author = "{Di Lazzaro}, Vincenzo and John Rothwell and Marco Capogna",

year = "2018",

month = jun,

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T1 - Noninvasive Stimulation of the Human Brain

T2 - Activation of Multiple Cortical Circuits

AU - Di Lazzaro, Vincenzo

AU - Rothwell, John

AU - Capogna, Marco

PY - 2018/6

Y1 - 2018/6

N2 - Noninvasive brain stimulation methods, such as transcranial electric stimulation and transcranial magnetic stimulation are widely used tools for both basic research and clinical applications. However, the cortical circuits underlying their effects are poorly defined. Here we review the current knowledge based on data mostly coming from experiments performed on human subjects, and also to a lesser extent on rodent or primate models. The data suggest that multiple mechanisms are likely to be involved, such as the direct activation of layer V pyramidal neurons, but also of different types of GABAergic interneurons. In this regard, we propose a key role for a specific type of interneuron known as neurogliaform cell.

AB - Noninvasive brain stimulation methods, such as transcranial electric stimulation and transcranial magnetic stimulation are widely used tools for both basic research and clinical applications. However, the cortical circuits underlying their effects are poorly defined. Here we review the current knowledge based on data mostly coming from experiments performed on human subjects, and also to a lesser extent on rodent or primate models. The data suggest that multiple mechanisms are likely to be involved, such as the direct activation of layer V pyramidal neurons, but also of different types of GABAergic interneurons. In this regard, we propose a key role for a specific type of interneuron known as neurogliaform cell.

KW - Journal Article

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KW - transcranial electrical stimulation

KW - cortical pyramidal neuron

KW - transcranial magnetic stimulation

KW - cortical interneuron

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KW - Transcranial Magnetic Stimulation

KW - Transcranial Direct Current Stimulation

KW - Animals

KW - Neural Pathways/physiology

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Noninvasive Stimulation of the Human Brain: Activation of Multiple Cortical Circuits

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Keywords

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