Non-infectious rhinitis is more strongly associated with early-rather than late-onset of COPD: data from the European Community Respiratory Health Survey (ECRHS)

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  • Joel Bergqvist, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Anders Andersson, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Linus Schiöler, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Anna-Carin Olin, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Nicola Murgia, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Mogens Bove, Novartis Sweden AB, Stockholm, Sweden., Sweden
  • Christer Janson, Uppsala University and Uppsala Clinical Research Center, Uppsala University, Sweden., Sweden
  • Michael J Abramson, Monash Med Ctr, Monash University, Monash Heart, Australia
  • Bénédicte Leynaert, Inserm UMR1152, Pathophysiology and Epidemiology of Respiratory Diseases, University of Paris, France
  • Dennis Nowak, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany
  • Karl A Franklin, Umeå University, Sweden
  • Isabelle Pin, Pneumologie Pédiatrique, Antenne Pédiatrique du CIC, Grenoble, France
  • Torgeir Storaas, SKS/RAAO-Helse Vest, Haukeland universitetssjukehus, Bergen, Norway
  • Vivi Schlünssen
  • Joachim Heinrich, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany
  • Johan Hellgren, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden

PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with several co-morbidities and non-infectious rhinitis (NIR) has emerged as a new possible co-morbidity. The primary aim of this study is to confirm a previously reported association between NIR and COPD in a multicentre population over time. The secondary aim is to investigate the course over time of such an association through a comparison between early- and late-onset COPD.

METHODS: This study is part of the European Community Respiratory Health Survey (ECRHS). A random adult population from 25 centres in Europe and one in Australia was examined with spirometry and answered a respiratory questionnaire in 1998-2002 (ECRHS II) and in 2008-2013 (ECRHS III). Symptoms of non-infectious rhinitis, hay fever and asthma, and smoking habits were reported. Subjects reporting asthma were excluded. COPD was defined as a spirometry ratio of FEV1/FVC < 0.7. A total of 5901 subjects were included.

RESULTS: Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < 0.001) in ECRHS II (mean age 43) but not in ECHRS III (mean age 54). In the multivariable regression model adjusted for COPD, smoking, age, BMI, and gender, non-infectious rhinitis was associated with COPD in both ECRHS II and III.

CONCLUSION: Non-infectious rhinitis was significantly more common in subjects with COPD at a mean age of 43. Ten years later, the association was weaker. The findings indicate that NIR could be associated with the early onset of COPD.

Original languageEnglish
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume277
Issue5
Pages (from-to)1353-1359
Number of pages7
ISSN0937-4477
DOIs
Publication statusPublished - May 2020

    Research areas

  • COPD, co-morbidity, epidemiology, rhinitis, spirometry

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