Noise sensitivity refers to physiological and psychological internal states of any individual, which increase the degree of reactivity to noise. There are only few studies on the neural mechanisms underlying noise sensitivity. Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP), generated in the supratemporal lobe of the brain, that is elicited by any discriminable change in some repetitive aspect of the ongoing auditory stimulation. In this study, we recruited 61 healthy adult subjects (age range 19-46 years) and measured their MMN to several sound feature changes inserted in a music-like sequence and administered the noise sensitivity questionnaire. With the help of this method we studied how the neural discrimination of sound changes (as indexed by MMN) is associated with noise sensitivity (as indexed by the questionnaire). The results showed that noise sensitivity had an influence on MMN to sound changes in timbre, with lower MMN responses in individuals with high noise-sensitivity scores than in those with low noise-sensitivity scores. According to the literature available this is the first study on this topic.