No beneficial effects of resveratrol on the metabolic syndrome: A randomized placebo-controlled clinical trial

TY - JOUR

T1 - No beneficial effects of resveratrol on the metabolic syndrome

T2 - A randomized placebo-controlled clinical trial

AU - Kjær, Thomas Nordstrøm

AU - Ornstrup, Marie Juul

AU - Poulsen, Morten Møller

AU - Stødkilde-Jørgensen, Hans

AU - Jessen, Niels

AU - Jørgensen, Jens Otto Lunde

AU - Richelsen, Bjørn

AU - Pedersen, Steen Bønløkke

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Context: Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has beneficial metabolic and anti-inflammatory effects that could have therapeutic implications. Objective: To investigate effects of long-term RSV treatment on inflammation and MetS. Setting and Design: A randomized, placebo-controlled, double-blind, parallel group clinical trial conducted at Aarhus University Hospital. Participants: Middle-aged community-dwelling men (N = 74) with MetS, 66 of whom completed all visits (mean6standard error of the mean): Age, 49.5 ± 0.796 years; bodymass index, 33.8 ± 0.44 kg/m 2; waist circumference, 115 6 1.14 cm. Intervention: Daily oral supplementation with 1000 mg RSV (RSV high), 150 mg RSV, or placebo for 16 weeks. Main outcome measures: Plasma levels of high-sensitivity C-reactive protein (hs-CRP), circulating lipids, and inflammatory markers in circulation and adipose/muscle tissue biopsy specimens; glucose metabolism; and body composition including visceral fat and ectopic fat deposition. Results: RSV treatment did not lower circulating levels of hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma, and inflammatory gene expression in adipose and muscle tissues also remained unchanged. RSV treatment had no effect on blood pressure, body composition, and lipid deposition in the liver or striated muscle. RSV treatment had no beneficial effect on glucose or lipid metabolism. RSVhigh treatment significantly increased total cholesterol (P < 0.002), low-density lipoprotein (LDL) cholesterol (P < 0.006), and fructosamine (P < 0.013) levels compared with placebo. Conclusion: RSV treatment did not improve inflammatory status, glucose homeostasis, blood pressure, or hepatic lipid content in middle-aged men with MetS. On the contrary, RSV high significantly increased total cholesterol, LDL cholesterol, and fructosamine levels compared with placebo.

AB - Context: Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has beneficial metabolic and anti-inflammatory effects that could have therapeutic implications. Objective: To investigate effects of long-term RSV treatment on inflammation and MetS. Setting and Design: A randomized, placebo-controlled, double-blind, parallel group clinical trial conducted at Aarhus University Hospital. Participants: Middle-aged community-dwelling men (N = 74) with MetS, 66 of whom completed all visits (mean6standard error of the mean): Age, 49.5 ± 0.796 years; bodymass index, 33.8 ± 0.44 kg/m 2; waist circumference, 115 6 1.14 cm. Intervention: Daily oral supplementation with 1000 mg RSV (RSV high), 150 mg RSV, or placebo for 16 weeks. Main outcome measures: Plasma levels of high-sensitivity C-reactive protein (hs-CRP), circulating lipids, and inflammatory markers in circulation and adipose/muscle tissue biopsy specimens; glucose metabolism; and body composition including visceral fat and ectopic fat deposition. Results: RSV treatment did not lower circulating levels of hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma, and inflammatory gene expression in adipose and muscle tissues also remained unchanged. RSV treatment had no effect on blood pressure, body composition, and lipid deposition in the liver or striated muscle. RSV treatment had no beneficial effect on glucose or lipid metabolism. RSVhigh treatment significantly increased total cholesterol (P < 0.002), low-density lipoprotein (LDL) cholesterol (P < 0.006), and fructosamine (P < 0.013) levels compared with placebo. Conclusion: RSV treatment did not improve inflammatory status, glucose homeostasis, blood pressure, or hepatic lipid content in middle-aged men with MetS. On the contrary, RSV high significantly increased total cholesterol, LDL cholesterol, and fructosamine levels compared with placebo.

UR - http://www.scopus.com/inward/record.url?scp=85014550884&partnerID=8YFLogxK

U2 - 10.1210/jc.2016-2160

DO - 10.1210/jc.2016-2160

M3 - Journal article

C2 - 28182820

SN - 0021-972X

VL - 102

SP - 1642

EP - 1651

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 5

ER -