Nitric oxide signalling and antidepressant action revisited

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  • Sâmia Joca
  • Ariandra Sartim, Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil., Brazil
  • Aline Roncalho, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil., Brazil
  • Cassiano Diniz, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil., Brazil
  • Gregers Wegener
Studies about the pathogenesis of mood disorders have consistently shown
that multiple factors, including genetic and environmental, play a crucial role
on their development and neurobiology. Multiple pathological theories have
been proposed, of which several ultimately affects or is a consequence of
dysfunction in brain neuroplasticity and homeostatic mechanisms. However,
current clinical available pharmacological intervention, which is predominantly
monoamine-based, suffers from partial and lacking response even after weeks of
continuous treatment. These issues raise the need for better understanding of
aetiologies and brain abnormalities in depression, as well as developing novel
treatment strategies. Nitric oxide (NO) is a gaseous unconventional neurotransmitter, which regulates and governs several important physiological functions in the central nervous system, including processes, which can be associated with the development of mood disorders. This review will present general aspects of the NO system in depression, highlighting potential targets which may be utilized and further explored as novel therapeutic targets in the future pharmacotherapy of depression. In particular, the review will link the importance of neuroplasticity mechanisms governed by NO to a possible molecular basis for the antidepressant effects.
Original languageEnglish
JournalCell and Tissue Research
ISSN0302-766X
DOIs
Publication statusE-pub ahead of print - 14 Jan 2019

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