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New roles of the human Suv3 helicase in genome maintenance

Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  • Susanne Trillingsgaard Venø, Denmark
During her PhD studies, Susanne Trillingsgaard Venø carried out research into the role of the human Suv3 protein in stabilising the human genome – DNA. Suv3 is a helicase that separates the two strands of the DNA’s double helix.

Throughout our lives, the DNA in our cells is constantly exposed to damage and this DNA damage accumulates as we get older. This accumulation of damage leads to a reduction in the function of the body’s organs, which can have a significant impact on the quality of life in our old age, as well as our lifespan. To enjoy a high quality of life free of illness therefore means that our cells must have some good tools to protect and repair our DNA.

Studies on mice have previously shown that a reduced level of the Suv3 protein causes the DNA of the mice to be less stable and more susceptible to damage. In addition, the mice age and die earlier than normal. In connection with her PhD project, Susanne Trillingsgaard Venø studied whether the Suv3 protein could be one of the cellular tools that contribute to maintaining DNA. By studying which other proteins the Suv3 works with in the cell, she produced completely new results that show how Suv3 can play a direct role in DNA maintenance.

Based on these new research results, the Suv3 protein could be a valuable model for genome stability as an important factor in our understanding of why we get old.
Original languageEnglish
PublisherAarhus University, Faculty of Science and Technology
Number of pages140
Commissioning bodyGraduate School of Science and Technology
Publication statusPublished - 20 Sep 2013

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