New Aspects of Earthworm Innate Immunity: Novel Molecules and Old Proteins With Unexpected Functions

TY - CHAP

T1 - New Aspects of Earthworm Innate Immunity

T2 - Novel Molecules and Old Proteins With Unexpected Functions

AU - Engelmann, Péter

AU - Hayashi, Yuya

AU - Bodó, Kornélia

AU - Molnár, László

PY - 2016/4/8

Y1 - 2016/4/8

N2 - The first exploration of earthworm immunity dates back almost the third quarter of a century. Since then, our journey has led to the discovery of several key biomolecules, some of which are common to invertebrates while some are rather specific to annelids. In light of these findings, we present the new aspects of earthworm immunity in an attempt to foresee potential research directions. We begin with a concise introduction before we discuss the newly described earthworm Toll receptors and their implications. Another key protein, lysenin, has historically been a popular target of research, yet its role in immunity remains obscured. We discuss, on the basis of our novel findings, how lysenin contributes to nanoparticle recognition in coelomocytes. The unique and conserved recognition strategies reviewed here have certainly opened up new research avenues and potentially harbor an intriguing clue for better elucidating the vertebrate immune response toward various antigens.

AB - The first exploration of earthworm immunity dates back almost the third quarter of a century. Since then, our journey has led to the discovery of several key biomolecules, some of which are common to invertebrates while some are rather specific to annelids. In light of these findings, we present the new aspects of earthworm immunity in an attempt to foresee potential research directions. We begin with a concise introduction before we discuss the newly described earthworm Toll receptors and their implications. Another key protein, lysenin, has historically been a popular target of research, yet its role in immunity remains obscured. We discuss, on the basis of our novel findings, how lysenin contributes to nanoparticle recognition in coelomocytes. The unique and conserved recognition strategies reviewed here have certainly opened up new research avenues and potentially harbor an intriguing clue for better elucidating the vertebrate immune response toward various antigens.

KW - Antimicrobial activity

KW - Coelomocyte

KW - Invertebrate immunity

KW - Lysenin

KW - Nanoparticle

KW - Opsonization

KW - Pattern recognition receptor

KW - Protein corona

KW - Toll

UR - http://www.scopus.com/inward/record.url?scp=84978655784&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-803252-7.00004-7

DO - 10.1016/B978-0-12-803252-7.00004-7

M3 - Book chapter

SN - 9780128032527

SP - 53

EP - 66

BT - Lessons in Immunity

A2 - Ballarin, Loriano

A2 - Cammarata, Matteo

PB - Elsevier

ER -