Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies

Miriam Højholt Terkelsen; Ida Hyllen Klæstrup; Victor Hvingelby; Johanne Lauritsen; Nicola Pavese; Marina Romero-Ramos

doi:10.3233/JPD-223245

Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies

Miriam Højholt Terkelsen, Ida Hyllen Klæstrup, Victor Hvingelby, Johanne Lauritsen, Nicola Pavese^*, Marina Romero-Ramos

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

30 Citations (Scopus)

Abstract

Multiple lines of clinical and pre-clinical research support a pathogenic role for neuroinflammation and peripheral immune system dysfunction in Parkinson's disease. In this paper, we have reviewed and summarised the published literature reporting evidence of neuroinflammation and peripheral immune changes in cohorts of patients with isolated REM sleep behaviour disorder and non-manifesting carriers of GBA or LRRK2 gene mutations, who have increased risk for Parkinsonism and synucleinopathies, and could be in the prodromal stage of these conditions. Taken together, the findings of these studies suggest that the early stages of pathology in Parkinsonism involve activation of both the central and peripheral immune systems with significant crosstalk. We consider these findings with respect to those found in patients with clinical Parkinson's disease and discuss their possible pathological roles. Moreover, those factors possibly associated with the immune response, such as the immunomodulatory role of the affected neurotransmitters and the changes in the gut-brain axis, are also considered.

Original language	English
Journal	Journal of Parkinson's Disease
Volume	12
Issue	s1
Pages (from-to)	S149-S163
ISSN	1877-7171
DOIs	https://doi.org/10.3233/JPD-223245
Publication status	Published - Sept 2022

Keywords

GBA
LRRK2
Microglia
Parkinson’s disease
T-cells
alpha-synuclein
monocytes
prodromal
Neuroinflammatory Diseases
Humans
Synucleinopathies
Prodromal Symptoms
Parkinson Disease/complications
REM Sleep Behavior Disorder/complications
alpha-Synuclein

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abstract = "Multiple lines of clinical and pre-clinical research support a pathogenic role for neuroinflammation and peripheral immune system dysfunction in Parkinson's disease. In this paper, we have reviewed and summarised the published literature reporting evidence of neuroinflammation and peripheral immune changes in cohorts of patients with isolated REM sleep behaviour disorder and non-manifesting carriers of GBA or LRRK2 gene mutations, who have increased risk for Parkinsonism and synucleinopathies, and could be in the prodromal stage of these conditions. Taken together, the findings of these studies suggest that the early stages of pathology in Parkinsonism involve activation of both the central and peripheral immune systems with significant crosstalk. We consider these findings with respect to those found in patients with clinical Parkinson's disease and discuss their possible pathological roles. Moreover, those factors possibly associated with the immune response, such as the immunomodulatory role of the affected neurotransmitters and the changes in the gut-brain axis, are also considered.",

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Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies. / Terkelsen, Miriam Højholt ; Klæstrup, Ida Hyllen ; Hvingelby, Victor et al.
In: Journal of Parkinson's Disease, Vol. 12, No. s1, 09.2022, p. S149-S163.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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AU - Terkelsen, Miriam Højholt

AU - Klæstrup, Ida Hyllen

AU - Hvingelby, Victor

AU - Lauritsen, Johanne

AU - Pavese, Nicola

AU - Romero-Ramos, Marina

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AB - Multiple lines of clinical and pre-clinical research support a pathogenic role for neuroinflammation and peripheral immune system dysfunction in Parkinson's disease. In this paper, we have reviewed and summarised the published literature reporting evidence of neuroinflammation and peripheral immune changes in cohorts of patients with isolated REM sleep behaviour disorder and non-manifesting carriers of GBA or LRRK2 gene mutations, who have increased risk for Parkinsonism and synucleinopathies, and could be in the prodromal stage of these conditions. Taken together, the findings of these studies suggest that the early stages of pathology in Parkinsonism involve activation of both the central and peripheral immune systems with significant crosstalk. We consider these findings with respect to those found in patients with clinical Parkinson's disease and discuss their possible pathological roles. Moreover, those factors possibly associated with the immune response, such as the immunomodulatory role of the affected neurotransmitters and the changes in the gut-brain axis, are also considered.

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KW - Prodromal Symptoms

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Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies

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Keywords

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