Neural responses during the anticipation and receipt of olfactory reward and punishment in human

TY - JOUR

T1 - Neural responses during the anticipation and receipt of olfactory reward and punishment in human

AU - Zou, Lai-Quan

AU - Zhou, Han-Yu

AU - Zhuang, Yuan

AU - van Hartevelt, Tim J

AU - Lui, Simon S Y

AU - Cheung, Eric F C

AU - Møller, Arne

AU - Kringelbach, Morten L

AU - Chan, Raymond C K

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/3

Y1 - 2018/3

N2 - Pleasure experience is an important part of normal healthy life and is essential for general and mental well-being. Many neuroimaging studies have investigated the underlying neural processing of verbal and visual modalities of reward. However, how the brain processes rewards in the olfactory modality is not fully understood. This study aimed to examine the neural basis of olfactory rewards in 25 healthy participants using functional magnetic resonance imaging (fMRI). We developed an Olfactory Incentive Delay (OLID) imaging task distinguishing between the anticipation and receipt of olfactory rewards and punishments. We found that the pallidum was activated during the anticipation of both olfactory rewards and punishments. The bilateral insula was activated independently from the odours' hedonic valence during the receipt phase. In addition, right caudate activation during the anticipation of unpleasant odours was correlated with self-reported anticipatory hedonic traits, whereas bilateral insular activation during the receipt of pleasant odours was correlated with self-reported consummatory hedonic traits. These findings suggest that activity in the insula and the caudate may be biomarkers of anhedonia. These findings also highlight a useful and valid paradigm to study the neural circuitry underlying reward processing in people with anhedonia.

AB - Pleasure experience is an important part of normal healthy life and is essential for general and mental well-being. Many neuroimaging studies have investigated the underlying neural processing of verbal and visual modalities of reward. However, how the brain processes rewards in the olfactory modality is not fully understood. This study aimed to examine the neural basis of olfactory rewards in 25 healthy participants using functional magnetic resonance imaging (fMRI). We developed an Olfactory Incentive Delay (OLID) imaging task distinguishing between the anticipation and receipt of olfactory rewards and punishments. We found that the pallidum was activated during the anticipation of both olfactory rewards and punishments. The bilateral insula was activated independently from the odours' hedonic valence during the receipt phase. In addition, right caudate activation during the anticipation of unpleasant odours was correlated with self-reported anticipatory hedonic traits, whereas bilateral insular activation during the receipt of pleasant odours was correlated with self-reported consummatory hedonic traits. These findings suggest that activity in the insula and the caudate may be biomarkers of anhedonia. These findings also highlight a useful and valid paradigm to study the neural circuitry underlying reward processing in people with anhedonia.

KW - Anticipation

KW - FMRI

KW - Hedonia

KW - Olfactory

KW - Pallidum

UR - http://www.scopus.com/inward/record.url?scp=85041737412&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2018.02.003

DO - 10.1016/j.neuropsychologia.2018.02.003

M3 - Journal article

C2 - 29408479

SN - 0028-3932

VL - 111

SP - 172

EP - 179

JO - Neuropsychologia

JF - Neuropsychologia

ER -