Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016

Yuelian Sun; Jesper Padkær Petersen; Chunsen Wu; Julie Werenberg Dreier; Rikke Damkjær Maimburg; Tine Brink Henriksen; Jakob Christensen

doi:10.2147/CLEP.S373289

Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016

Yuelian Sun, Jesper Padkær Petersen, Chunsen Wu, Julie Werenberg Dreier, Rikke Damkjær Maimburg, Tine Brink Henriksen, Jakob Christensen

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Abstract

PURPOSE: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the Danish National Patient Registry (DNPR) and the clinical characteristics of neonates treated with phototherapy.

METHODS: We identified children born alive in Denmark from 1 January 2000 through 30 November 2016 from the DNPR (N=1,044,502). We calculated the proportion of children registered that received phototherapy during the neonatal period and examined temporal trends, both nationwide and at the level of individual hospitals. In a sub-cohort of children born at Aarhus University Hospital (AUH) in 2002-2016 (N=71,781), we analyzed the proportions of children registered that received phototherapy, according to sex, gestational age, birth weight, and neonatal characteristics, like Apgar score, birth asphyxia, and infections.

RESULTS: We identified 11,295 (1.1%) registered that received phototherapy. The proportions of children registered that received phototherapy differed among hospitals (range: 0 to 4.1%). Nationwide registration was low during the study period, but it increased to 1.8% in 2016. For the AUH sub-cohort the proportion of children registered with phototherapy averaged 4.4% (N=3182, range:3.9-5.1%). The proportion of children registered with phototherapy was inversely correlated with gestational age and birth weight, and positively correlated with neonatal characteristics, including low Apgar score, birth asphyxia, and infections.

CONCLUSION: Phototherapy was under-reported in the DNPR and the proportions of children registered that received phototherapy differed among hospitals. The non-compulsory policy for reporting treatment and care in hospitals to the DNPR might explain the variation. The most consistent reporting was observed among children born in an university hospital, where 4.4% of children registered that received phototherapy, and phototherapy was inversely associated with gestational age, birth weight, and positively associated with clinical characteristics like birth asphyxia, and infections.

Original language	English
Journal	Clinical epidemiology
Volume	15
Pages (from-to)	123-136
Number of pages	14
ISSN	1179-1349
DOIs	https://doi.org/10.2147/CLEP.S373289
Publication status	Published - Jan 2023

Keywords

Danish National Patient Registry
health administrative data
hyperbilirubinemia
neonatal jaundice
neonates
phototherapy

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CLEP-373289-neonatal-phototherapy-and-clinical-characteristics--the-daniFinal published version, 4.73 MBLicence: CC BY-NC

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@article{31006005821e4314ae1925b0e50eaa94,

title = "Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016",

abstract = "PURPOSE: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the Danish National Patient Registry (DNPR) and the clinical characteristics of neonates treated with phototherapy.METHODS: We identified children born alive in Denmark from 1 January 2000 through 30 November 2016 from the DNPR (N=1,044,502). We calculated the proportion of children registered that received phototherapy during the neonatal period and examined temporal trends, both nationwide and at the level of individual hospitals. In a sub-cohort of children born at Aarhus University Hospital (AUH) in 2002-2016 (N=71,781), we analyzed the proportions of children registered that received phototherapy, according to sex, gestational age, birth weight, and neonatal characteristics, like Apgar score, birth asphyxia, and infections.RESULTS: We identified 11,295 (1.1%) registered that received phototherapy. The proportions of children registered that received phototherapy differed among hospitals (range: 0 to 4.1%). Nationwide registration was low during the study period, but it increased to 1.8% in 2016. For the AUH sub-cohort the proportion of children registered with phototherapy averaged 4.4% (N=3182, range:3.9-5.1%). The proportion of children registered with phototherapy was inversely correlated with gestational age and birth weight, and positively correlated with neonatal characteristics, including low Apgar score, birth asphyxia, and infections.CONCLUSION: Phototherapy was under-reported in the DNPR and the proportions of children registered that received phototherapy differed among hospitals. The non-compulsory policy for reporting treatment and care in hospitals to the DNPR might explain the variation. The most consistent reporting was observed among children born in an university hospital, where 4.4% of children registered that received phototherapy, and phototherapy was inversely associated with gestational age, birth weight, and positively associated with clinical characteristics like birth asphyxia, and infections.",

keywords = "Danish National Patient Registry, health administrative data, hyperbilirubinemia, neonatal jaundice, neonates, phototherapy",

author = "Yuelian Sun and Petersen, {Jesper Padk{\ae}r} and Chunsen Wu and Dreier, {Julie Werenberg} and Maimburg, {Rikke Damkj{\ae}r} and Henriksen, {Tine Brink} and Jakob Christensen",

note = "{\textcopyright} 2023 Sun et al.",

year = "2023",

month = jan,

doi = "10.2147/CLEP.S373289",

language = "English",

volume = "15",

pages = "123--136",

journal = "Clinical epidemiology",

issn = "1179-1349",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Neonatal Phototherapy and Clinical Characteristics

T2 - The Danish National Patient Registry 2000-2016

AU - Sun, Yuelian

AU - Petersen, Jesper Padkær

AU - Wu, Chunsen

AU - Dreier, Julie Werenberg

AU - Maimburg, Rikke Damkjær

AU - Henriksen, Tine Brink

AU - Christensen, Jakob

PY - 2023/1

Y1 - 2023/1

N2 - PURPOSE: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the Danish National Patient Registry (DNPR) and the clinical characteristics of neonates treated with phototherapy.METHODS: We identified children born alive in Denmark from 1 January 2000 through 30 November 2016 from the DNPR (N=1,044,502). We calculated the proportion of children registered that received phototherapy during the neonatal period and examined temporal trends, both nationwide and at the level of individual hospitals. In a sub-cohort of children born at Aarhus University Hospital (AUH) in 2002-2016 (N=71,781), we analyzed the proportions of children registered that received phototherapy, according to sex, gestational age, birth weight, and neonatal characteristics, like Apgar score, birth asphyxia, and infections.RESULTS: We identified 11,295 (1.1%) registered that received phototherapy. The proportions of children registered that received phototherapy differed among hospitals (range: 0 to 4.1%). Nationwide registration was low during the study period, but it increased to 1.8% in 2016. For the AUH sub-cohort the proportion of children registered with phototherapy averaged 4.4% (N=3182, range:3.9-5.1%). The proportion of children registered with phototherapy was inversely correlated with gestational age and birth weight, and positively correlated with neonatal characteristics, including low Apgar score, birth asphyxia, and infections.CONCLUSION: Phototherapy was under-reported in the DNPR and the proportions of children registered that received phototherapy differed among hospitals. The non-compulsory policy for reporting treatment and care in hospitals to the DNPR might explain the variation. The most consistent reporting was observed among children born in an university hospital, where 4.4% of children registered that received phototherapy, and phototherapy was inversely associated with gestational age, birth weight, and positively associated with clinical characteristics like birth asphyxia, and infections.

AB - PURPOSE: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the Danish National Patient Registry (DNPR) and the clinical characteristics of neonates treated with phototherapy.METHODS: We identified children born alive in Denmark from 1 January 2000 through 30 November 2016 from the DNPR (N=1,044,502). We calculated the proportion of children registered that received phototherapy during the neonatal period and examined temporal trends, both nationwide and at the level of individual hospitals. In a sub-cohort of children born at Aarhus University Hospital (AUH) in 2002-2016 (N=71,781), we analyzed the proportions of children registered that received phototherapy, according to sex, gestational age, birth weight, and neonatal characteristics, like Apgar score, birth asphyxia, and infections.RESULTS: We identified 11,295 (1.1%) registered that received phototherapy. The proportions of children registered that received phototherapy differed among hospitals (range: 0 to 4.1%). Nationwide registration was low during the study period, but it increased to 1.8% in 2016. For the AUH sub-cohort the proportion of children registered with phototherapy averaged 4.4% (N=3182, range:3.9-5.1%). The proportion of children registered with phototherapy was inversely correlated with gestational age and birth weight, and positively correlated with neonatal characteristics, including low Apgar score, birth asphyxia, and infections.CONCLUSION: Phototherapy was under-reported in the DNPR and the proportions of children registered that received phototherapy differed among hospitals. The non-compulsory policy for reporting treatment and care in hospitals to the DNPR might explain the variation. The most consistent reporting was observed among children born in an university hospital, where 4.4% of children registered that received phototherapy, and phototherapy was inversely associated with gestational age, birth weight, and positively associated with clinical characteristics like birth asphyxia, and infections.

KW - Danish National Patient Registry

KW - health administrative data

KW - hyperbilirubinemia

KW - neonatal jaundice

KW - neonates

KW - phototherapy

U2 - 10.2147/CLEP.S373289

DO - 10.2147/CLEP.S373289

M3 - Journal article

C2 - 36721458

SN - 1179-1349

VL - 15

SP - 123

EP - 136

JO - Clinical epidemiology

JF - Clinical epidemiology

ER -

Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016

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Keywords

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