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Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells.

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Standard

Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. / Nissen, Poul; Jensen, Anne-Marie Lund; Møller, Jesper Vuust; Christensen, Søren Brøgger; Søhoel, Helmer; Olsen, C. E.; Denmeade, S. R.; Isaacs, John T.

In: Bioorganic and Medicinal Chemistry, Vol. 14, No. 8, 2006, p. 2810-2815.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nissen, P, Jensen, A-ML, Møller, JV, Christensen, SB, Søhoel, H, Olsen, CE, Denmeade, SR & Isaacs, JT 2006, 'Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells.', Bioorganic and Medicinal Chemistry, vol. 14, no. 8, pp. 2810-2815.

APA

Nissen, P., Jensen, A-M. L., Møller, J. V., Christensen, S. B., Søhoel, H., Olsen, C. E., Denmeade, S. R., & Isaacs, J. T. (2006). Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorganic and Medicinal Chemistry, 14(8), 2810-2815.

CBE

Nissen P, Jensen A-ML, Møller JV, Christensen SB, Søhoel H, Olsen CE, Denmeade SR, Isaacs JT. 2006. Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorganic and Medicinal Chemistry. 14(8):2810-2815.

MLA

Vancouver

Nissen P, Jensen A-ML, Møller JV, Christensen SB, Søhoel H, Olsen CE et al. Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorganic and Medicinal Chemistry. 2006;14(8):2810-2815.

Author

Nissen, Poul ; Jensen, Anne-Marie Lund ; Møller, Jesper Vuust ; Christensen, Søren Brøgger ; Søhoel, Helmer ; Olsen, C. E. ; Denmeade, S. R. ; Isaacs, John T. / Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. In: Bioorganic and Medicinal Chemistry. 2006 ; Vol. 14, No. 8. pp. 2810-2815.

Bibtex

@article{3b15ee00c65e11dbbee902004c4f4f50,
title = "Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells.",
abstract = "An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic",
author = "Poul Nissen and Jensen, {Anne-Marie Lund} and M{\o}ller, {Jesper Vuust} and Christensen, {S{\o}ren Br{\o}gger} and Helmer S{\o}hoel and Olsen, {C. E.} and Denmeade, {S. R.} and Isaacs, {John T.}",
note = "MeSH Terms: Animals Calcium-Transporting ATPases/antagonists & inhibitors* Cell Line, Tumor Humans Male Mass Spectrometry Models, Molecular Prostatic Neoplasms/enzymology Prostatic Neoplasms/pathology* Rabbits Sarcoplasmic Reticulum Calcium-Transporting ATPases",
year = "2006",
language = "English",
volume = "14",
pages = "2810--2815",
journal = "Bioorganic and Medicinal Chemistry",
number = "8",

}

RIS

TY - JOUR

T1 - Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells.

AU - Nissen, Poul

AU - Jensen, Anne-Marie Lund

AU - Møller, Jesper Vuust

AU - Christensen, Søren Brøgger

AU - Søhoel, Helmer

AU - Olsen, C. E.

AU - Denmeade, S. R.

AU - Isaacs, John T.

N1 - MeSH Terms: Animals Calcium-Transporting ATPases/antagonists & inhibitors* Cell Line, Tumor Humans Male Mass Spectrometry Models, Molecular Prostatic Neoplasms/enzymology Prostatic Neoplasms/pathology* Rabbits Sarcoplasmic Reticulum Calcium-Transporting ATPases

PY - 2006

Y1 - 2006

N2 - An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic

AB - An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic

M3 - Journal article

VL - 14

SP - 2810

EP - 2815

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 8

ER -