Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy

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  • Ling-xiao Zhang, Chinese Academy of Sciences, Beijing, The University of Queensland, University of Chinese Academy of Sciences
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  • Xia-mei Sun, Chinese Academy of Sciences, Beijing
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  • Ying-bo Jia, Chinese Academy of Sciences, Beijing, University of Chinese Academy of Sciences
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  • Xiao-ge Liu, Chinese Academy of Sciences, Beijing, University of Chinese Academy of Sciences
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  • Mingdong Dong
  • Zhi Ping Xu, The University of Queensland
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  • Rui tian Liu, Chinese Academy of Sciences, Beijing

The advantage of rapid tumor growth over slow immune induction often limits the efficiency of cancer therapeutic vaccines. Many functionalized micro-/nano-vaccines are shown to enhance cancer immunotherapy, but few studies correlate the therapeutic efficacy of these micro-/nano-vaccines to the vaccination route such as intravenous (IV), subcutaneous (SC) injection or their combination. Herein, we employed classical “priming + boosting” vaccination strategy to investigate the influence of four vaccination combinations (IV + IV, IV + SC, SC + IV and SC + SC) of nanovaccines on the anti-tumor therapeutic efficacy in mice bearing E.G7-OVA-lymphoma and B16F10-melanoma. The nanovaccines were constructed by loading antigen and CpG onto layered double hydroxide (LDH) nanoparticles. Our experimental data indicate that “IV-priming + SC-boosting” vaccination combination most efficiently inhibits the growth of early stage tumors, with the tumor volume reduced by >75-90 % in comparison with the control group. Based on these findings, a novel vaccination strategy, i.e. simultaneous IV and SC injection was proposed, which significantly delayed the progression of both early stage and advanced B16F10 tumors. Our current research for the first time correlates the vaccination route of nanovaccines to the anti-tumor therapeutic efficacy, and the highest efficacy of optimal vaccination combination (IV + SC) is benefited from that fact that IV priming quickly induces strong anti-tumor responses that are well sustained by subsequent SC boosting. Moreover, the simultaneous IV/SC vaccination potentially provides a novel vaccination strategy for enhanced immunotherapy of early stage and advanced tumors.

Original languageEnglish
Article number100923
JournalNano Today
Number of pages12
Publication statusPublished - Dec 2020

    Research areas

  • Layered double hydroxide based nanovaccine, Malignant cancer immunotherapy, Quick induction of anti-tumor immunity, Vaccination routes

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