Nano–Bio Interface of Molybdenum Disulfide for Biological Applications

Rongrong Wu; Mingdong Dong; Lei Liu

doi:10.3390/coatings13061122

Nano–Bio Interface of Molybdenum Disulfide for Biological Applications

Rongrong Wu, Mingdong Dong, Lei Liu^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

5 Citations (Scopus)

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Abstract

The unique nano–bio interfacial phenomena play a crucial role in the biosafety and bioapplications of nanomaterials. As a representative two-dimensional (2D) nanomaterial, molybdenum disulfide (MoS₂) has shown great potential in biological applications due to its low toxicity and fascinating physicochemical properties. This review aims to highlight the nano–bio interface of MoS₂ nanomaterials with the major biomolecules and the implications of their biosafety and novel bioapplications. First, the nano–bio interactions of MoS₂ with amino acids, peptides, proteins, lipid membranes, and nucleic acids, as well as the associated applications in protein detection, DNA sequencing, antimicrobial activities, and wound-healing are introduced. Furthermore, to facilitate broader biomedical applications, we extensively evaluated the toxicity of MoS₂ and discussed the strategies for functionalization through interactions among MoS₂ and the variety of macromolecules to enhance the biocompatibility. Overall, understanding the nano–bio interface interaction of two-dimensional nanomaterials is significant for understanding their biocompatibility and biosafety, and further provide guidance for better biological applications in the future.

Original language	English
Article number	1122
Journal	Coatings
Volume	13
Issue	6
Number of pages	22
DOIs	https://doi.org/10.3390/coatings13061122
Publication status	Published - Jun 2023

Keywords

biocompatibility and biosafety
biological antibacterial
biosensor detection
molybdenum disulfide
nano–bio interfacial interactions

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coatings-13-01122-v2Final published version, 7.59 MBLicence: CC BY

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title = "Nano–Bio Interface of Molybdenum Disulfide for Biological Applications",

abstract = "The unique nano–bio interfacial phenomena play a crucial role in the biosafety and bioapplications of nanomaterials. As a representative two-dimensional (2D) nanomaterial, molybdenum disulfide (MoS2) has shown great potential in biological applications due to its low toxicity and fascinating physicochemical properties. This review aims to highlight the nano–bio interface of MoS2 nanomaterials with the major biomolecules and the implications of their biosafety and novel bioapplications. First, the nano–bio interactions of MoS2 with amino acids, peptides, proteins, lipid membranes, and nucleic acids, as well as the associated applications in protein detection, DNA sequencing, antimicrobial activities, and wound-healing are introduced. Furthermore, to facilitate broader biomedical applications, we extensively evaluated the toxicity of MoS2 and discussed the strategies for functionalization through interactions among MoS2 and the variety of macromolecules to enhance the biocompatibility. Overall, understanding the nano–bio interface interaction of two-dimensional nanomaterials is significant for understanding their biocompatibility and biosafety, and further provide guidance for better biological applications in the future.",

keywords = "biocompatibility and biosafety, biological antibacterial, biosensor detection, molybdenum disulfide, nano–bio interfacial interactions",

author = "Rongrong Wu and Mingdong Dong and Lei Liu",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jun,

doi = "10.3390/coatings13061122",

language = "English",

volume = "13",

journal = "Coatings",

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T1 - Nano–Bio Interface of Molybdenum Disulfide for Biological Applications

AU - Wu, Rongrong

AU - Dong, Mingdong

AU - Liu, Lei

PY - 2023/6

Y1 - 2023/6

N2 - The unique nano–bio interfacial phenomena play a crucial role in the biosafety and bioapplications of nanomaterials. As a representative two-dimensional (2D) nanomaterial, molybdenum disulfide (MoS2) has shown great potential in biological applications due to its low toxicity and fascinating physicochemical properties. This review aims to highlight the nano–bio interface of MoS2 nanomaterials with the major biomolecules and the implications of their biosafety and novel bioapplications. First, the nano–bio interactions of MoS2 with amino acids, peptides, proteins, lipid membranes, and nucleic acids, as well as the associated applications in protein detection, DNA sequencing, antimicrobial activities, and wound-healing are introduced. Furthermore, to facilitate broader biomedical applications, we extensively evaluated the toxicity of MoS2 and discussed the strategies for functionalization through interactions among MoS2 and the variety of macromolecules to enhance the biocompatibility. Overall, understanding the nano–bio interface interaction of two-dimensional nanomaterials is significant for understanding their biocompatibility and biosafety, and further provide guidance for better biological applications in the future.

AB - The unique nano–bio interfacial phenomena play a crucial role in the biosafety and bioapplications of nanomaterials. As a representative two-dimensional (2D) nanomaterial, molybdenum disulfide (MoS2) has shown great potential in biological applications due to its low toxicity and fascinating physicochemical properties. This review aims to highlight the nano–bio interface of MoS2 nanomaterials with the major biomolecules and the implications of their biosafety and novel bioapplications. First, the nano–bio interactions of MoS2 with amino acids, peptides, proteins, lipid membranes, and nucleic acids, as well as the associated applications in protein detection, DNA sequencing, antimicrobial activities, and wound-healing are introduced. Furthermore, to facilitate broader biomedical applications, we extensively evaluated the toxicity of MoS2 and discussed the strategies for functionalization through interactions among MoS2 and the variety of macromolecules to enhance the biocompatibility. Overall, understanding the nano–bio interface interaction of two-dimensional nanomaterials is significant for understanding their biocompatibility and biosafety, and further provide guidance for better biological applications in the future.

KW - biocompatibility and biosafety

KW - biological antibacterial

KW - biosensor detection

KW - molybdenum disulfide

KW - nano–bio interfacial interactions

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U2 - 10.3390/coatings13061122

DO - 10.3390/coatings13061122

M3 - Review

AN - SCOPUS:85164189813

SN - 2079-6412

VL - 13

JO - Coatings

JF - Coatings

IS - 6

M1 - 1122

ER -

Nano–Bio Interface of Molybdenum Disulfide for Biological Applications

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