Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm

Jonas Palle; Nina Kølln Wittig; Adam Kubec; Sven Niese; Martin Rosenthal; Manfred Burghammer; Tilman A. Grünewald; Henrik Birkedal

doi:10.1016/j.jsb.2020.107631

Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm

Jonas Palle, Nina Kølln Wittig, Adam Kubec, Sven Niese, Martin Rosenthal, Manfred Burghammer, Tilman A. Grünewald, Henrik Birkedal^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

20 Citations (Scopus)

Abstract

Studying nanostructured hierarchical materials such as the biomineralized bone is challenging due to their complex 3D structures that call for high spatial resolution. One route to study such materials is X-ray powder diffraction computed tomography (XRD-CT) that reveals the 3D distribution of crystalline phases and X-ray fluorescence computed tomography (XRF-CT) that provides element distributions. However, the spatial resolution of XRD-CT has thus far been limited. Here we demonstrate better than 120 nm 3D resolution on human bone in XRD-CT and XRF-CT measured simultaneously using X-ray nanobeams. The results pave the way for nanoscale 3D characterization of nanocrystalline composites like bone at unprecedented detail.

Original language	English
Article number	107631
Journal	Journal of Structural Biology
Volume	212
Issue	3
Number of pages	6
ISSN	1047-8477
DOIs	https://doi.org/10.1016/j.jsb.2020.107631
Publication status	Published - Dec 2020

Keywords

Bone
Multilayer laue lenses
Tomography
X-ray fluorescence computed tomography (XRF-CT)
X-ray nanobeams
X-ray powder diffraction computed tomography (XRD-CT)

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10.1016/j.jsb.2020.107631

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@article{6b509158b34b45fc9db94f83a01a5969,

title = "Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm",

abstract = "Studying nanostructured hierarchical materials such as the biomineralized bone is challenging due to their complex 3D structures that call for high spatial resolution. One route to study such materials is X-ray powder diffraction computed tomography (XRD-CT) that reveals the 3D distribution of crystalline phases and X-ray fluorescence computed tomography (XRF-CT) that provides element distributions. However, the spatial resolution of XRD-CT has thus far been limited. Here we demonstrate better than 120 nm 3D resolution on human bone in XRD-CT and XRF-CT measured simultaneously using X-ray nanobeams. The results pave the way for nanoscale 3D characterization of nanocrystalline composites like bone at unprecedented detail.",

keywords = "Bone, Multilayer laue lenses, Tomography, X-ray fluorescence computed tomography (XRF-CT), X-ray nanobeams, X-ray powder diffraction computed tomography (XRD-CT)",

author = "Jonas Palle and Wittig, {Nina K{\o}lln} and Adam Kubec and Sven Niese and Martin Rosenthal and Manfred Burghammer and Gr{\"u}newald, {Tilman A.} and Henrik Birkedal",

year = "2020",

month = dec,

doi = "10.1016/j.jsb.2020.107631",

language = "English",

volume = "212",

journal = "Journal of Structural Biology",

issn = "1047-8477",

publisher = "Academic Press Inc.",

number = "3",

}

Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm. / Palle, Jonas; Wittig, Nina Kølln; Kubec, Adam et al.
In: Journal of Structural Biology, Vol. 212, No. 3, 107631, 12.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm

AU - Palle, Jonas

AU - Wittig, Nina Kølln

AU - Kubec, Adam

AU - Niese, Sven

AU - Rosenthal, Martin

AU - Burghammer, Manfred

AU - Grünewald, Tilman A.

AU - Birkedal, Henrik

PY - 2020/12

Y1 - 2020/12

N2 - Studying nanostructured hierarchical materials such as the biomineralized bone is challenging due to their complex 3D structures that call for high spatial resolution. One route to study such materials is X-ray powder diffraction computed tomography (XRD-CT) that reveals the 3D distribution of crystalline phases and X-ray fluorescence computed tomography (XRF-CT) that provides element distributions. However, the spatial resolution of XRD-CT has thus far been limited. Here we demonstrate better than 120 nm 3D resolution on human bone in XRD-CT and XRF-CT measured simultaneously using X-ray nanobeams. The results pave the way for nanoscale 3D characterization of nanocrystalline composites like bone at unprecedented detail.

AB - Studying nanostructured hierarchical materials such as the biomineralized bone is challenging due to their complex 3D structures that call for high spatial resolution. One route to study such materials is X-ray powder diffraction computed tomography (XRD-CT) that reveals the 3D distribution of crystalline phases and X-ray fluorescence computed tomography (XRF-CT) that provides element distributions. However, the spatial resolution of XRD-CT has thus far been limited. Here we demonstrate better than 120 nm 3D resolution on human bone in XRD-CT and XRF-CT measured simultaneously using X-ray nanobeams. The results pave the way for nanoscale 3D characterization of nanocrystalline composites like bone at unprecedented detail.

KW - Bone

KW - Multilayer laue lenses

KW - Tomography

KW - X-ray fluorescence computed tomography (XRF-CT)

KW - X-ray nanobeams

KW - X-ray powder diffraction computed tomography (XRD-CT)

UR - http://www.scopus.com/inward/record.url?scp=85091741094&partnerID=8YFLogxK

U2 - 10.1016/j.jsb.2020.107631

DO - 10.1016/j.jsb.2020.107631

M3 - Journal article

C2 - 32980520

AN - SCOPUS:85091741094

SN - 1047-8477

VL - 212

JO - Journal of Structural Biology

JF - Journal of Structural Biology

IS - 3

M1 - 107631

ER -

Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm

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Keywords

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