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NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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DOI

  • Yujun Hou, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Sofie Lautrup, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Stephanie Cordonnier, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Yue Wang, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
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  • Deborah L Croteau, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Eduardo Zavala, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Yongqing Zhang, Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
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  • Kanako Moritoh, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
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  • Jennifer F O'Connell, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
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  • Beverly A Baptiste, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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  • Tinna V Stevnsner
  • Mark P Mattson, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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  • Vilhelm A Bohr, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; vbohr@nih.gov., Danish Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen, Denmark.
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue8
Pages (from-to)E1876-E1885
Number of pages10
ISSN0027-8424
DOIs
Publication statusPublished - 20 Feb 2018

    Research areas

  • Journal Article

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